Long-term Effects of Lifestyle Intervention in Obesity and Genetic Influence (LOGIC)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01067157
Recruitment Status : Active, not recruiting
First Posted : February 11, 2010
Last Update Posted : September 29, 2017
Klinik Schönsicht, Berchtesgaden, Germany
Information provided by (Responsible Party):
Technische Universität München

February 10, 2010
February 11, 2010
September 29, 2017
January 1, 2006
December 31, 2013   (Final data collection date for primary outcome measure)
Influence of gene variants in FTO, MC4R and TMEM-18 on reduction of overweight and obesity measured by standard deviation score Body Mass Index (sds-BMI) [ Time Frame: 16 years ]
Same as current
Complete list of historical versions of study NCT01067157 on Archive Site
Not Provided
Not Provided
Not Provided
Not Provided
Long-term Effects of Lifestyle Intervention in Obesity and Genetic Influence
Long-term Effects of Lifestyle Intervention in Obesity and Genetic Influence in Children - LOGIC-Study
The purpose of the study is to determine the genetic influence on short-, middle- and longterm effects of an inpatient lifestyle therapy program in overweight and obese children and adolescents.

In Germany, as in other countries, overweight and obesity affects a growing number of children and adolescents. Obesity-related diseases such as arterial hypertension, disorders of glucose and lipid metabolism and an increase in inflammation markers are associated with higher morbidity and mortality in early life, therefore effective therapy concepts are needed.

The aim of this study is to evaluate the effects of a 4-6 week inpatient obesity lifestyle therapy program over 10 years and the genetic influence on the short-, middle- and longterm outcome.

The lifestyle intervention consists of physical exercise, nutrition education and behaviour therapy based on the criterions developed by the German Obesity Group (degree of weight reduction, improvement of comorbidity and health behaviour, minimising of side effects).

Not Applicable
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
  • Obesity
  • Cardiovascular Risk
Behavioral: LOGIC

Experimental group:

Diet (1200-1800 kcal/d), Exercise: 11 h/wk physical activity, Behavioural therapy (group training, 1-3h/wk individualized personal instructions, 2 h parents work)


Other = Lifestyle intervention

A: Medical examination before and after inpatient therapy (clinic staff), questionnaires.

Further medical examination and questionnaires after 6 months, 1, 2, 5 and 10 years at home by pediatrics or general practitioner.

The lifestyle intervention includes an age-specific diet (1200-1800 kcal/d), 11 h/wk physical activity (walking, swimming, sports) and behavioural therapy.

Intervention: Behavioral: LOGIC

*   Includes publications given by the data provider as well as publications identified by Identifier (NCT Number) in Medline.
Active, not recruiting
Same as current
July 2022
December 31, 2013   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • Overweight or obese children (BMI >90th percentile for age and gender), who obtained an inpatient lifestyle intervention in the participating clinic.
  • Children with written consent from their parents and the acceptance of a 10-year follow-up.

Exclusion Criteria:

  • Children without written consent from their parents.
  • Children with mongenetic diseases with influence on obesity (e.g. Prader-Willi-Syndrom) or with secondary obesity.
Sexes Eligible for Study: All
6 Years to 19 Years   (Child, Adult)
Contact information is only displayed when the study is recruiting subjects
Not Provided
Not Provided
Technische Universität München
Technische Universität München
Klinik Schönsicht, Berchtesgaden, Germany
Study Chair: Martin Halle, Prof. M.D. Department of Medicine, Division of Prevention, Rehabilitation and Sports Medicine, Technical University Munich, Germany
Technische Universität München
September 2017

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP