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Copeptin in Differentiation of Polyuria and Polydipsia

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01056887
First Posted: January 26, 2010
Last Update Posted: April 25, 2011
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborator:
Dr. Carson Liu Med Corp.
Information provided by:
University of Wuerzburg
January 25, 2010
January 26, 2010
April 25, 2011
March 2008
November 2010   (Final data collection date for primary outcome measure)
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Complete list of historical versions of study NCT01056887 on ClinicalTrials.gov Archive Site
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Copeptin in Differentiation of Polyuria and Polydipsia
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The differential diagnosis of patients with polyuria/ polydipsia is often complex, but important for the therapeutic strategy.

Challenging is in particular the clinical differentiation between patients with a partial Diabetes insipidus centralis and patients with primary polydipsia as underlying disease, because both groups are associated with similar urinary osmolalities.

The determination of plasma arginine vasopressin is unusual in this context, since measurement of AVP is not reliably.

C-terminal ProVasopressin (copeptin) is secreted stoichiometrically with AVP from the neurohypophysis, but has a longer half life in the circulation, and is thus easier to measure.

Therefore, the investigators will analyze in that study the diagnostic utility of plasma copeptin in the differential diagnosis of polyuria and polydipsia.

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Observational
Observational Model: Cohort
Time Perspective: Prospective
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Probability Sample
Healthy probands Patients with diabetes insipdus centralis totalis/ partials Patients with diabetes insipidus renalis Patients with primary polydipsia
  • Polyuria
  • Polydipsia
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Primary Polydip, D. insipidus
Fenske W, Quinkler M, Lorenz D, Zopf K, Haagen U, Papassotiriou J, Pfeiffer AF, Fassnacht M, Störk S, Allolio B. Copeptin in the differential diagnosis of the polydipsia-polyuria syndrome--revisiting the direct and indirect water deprivation tests. J Clin Endocrinol Metab. 2011 May;96(5):1506-15. doi: 10.1210/jc.2010-2345. Epub 2011 Mar 2.

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
50
November 2010
November 2010   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • Patients with polydipsia/ polyuria, with indication for performing a deprivation test
  • > 18 years

Exclusion Criteria:

  • dDAVP during the last 14d
  • pregnancy
Sexes Eligible for Study: All
18 Years to 70 Years   (Adult, Senior)
Yes
Contact information is only displayed when the study is recruiting subjects
Germany
 
 
NCT01056887
17121979
33/07
Yes
Not Provided
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Prof. Dr. med. Bruno Allolio, FDAAA
University of Wuerzburg
Dr. Carson Liu Med Corp.
Not Provided
University of Wuerzburg
November 2010