Collagen Analysis and Genetic Analysis of Families With Tendency to Hernias

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00991484
Recruitment Status : Unknown
Verified October 2010 by Herlev Hospital.
Recruitment status was:  Recruiting
First Posted : October 8, 2009
Last Update Posted : October 13, 2010
Information provided by:
Herlev Hospital

October 7, 2009
October 8, 2009
October 13, 2010
December 2009
December 2010   (Final data collection date for primary outcome measure)
Expression of collagen-genes or other relevant genes by microarray analysis compared with presence of hernia [ Time Frame: 1 year ]
Same as current
Complete list of historical versions of study NCT00991484 on Archive Site
Amount of collagen subtypes measured subcutaneously. [ Time Frame: 1 year ]
Same as current
Not Provided
Not Provided
Collagen Analysis and Genetic Analysis of Families With Tendency to Hernias
Collagen-subtype Analysis in Subcutaneous Tissue and Genetic Analysis on Patients From Families With a Tendency to Hernias
Analysis of collagen subtype subcutaneously and genetic analysis of patients from families with a tendency to hernias. Furthermore circulating biomarkers and biomarkers extracted from the subcutaneously tissue such as MMP's (matrix metallo proteinases) and TIMP's (tissue inhibitor of metallo proteinases) will be measured.

Research has shown relationship between hernias and collagen subtype I/III ratio, biomarkers such as MMP's TIMP's and other diseases such as Ehlers-Danlos, Marfans syndrome, AAA (abdominal aortic aneurysms), diverticulosis and rectal prolapse. Furthermore has research raised hypothesis about inheritance of hernias. The investigators are performing genetic examination combined with analysis of collagen and biomarkers on patients belonging to families with tendency to hernias.

Other examinations performed on the patients enrolled in this study:

  • Ultrasound (US) examination of the abdominal aorta to discover possible abdominal aortic aneurysms.
  • Beightons score to evaluate the degree of joint hypermobility.
Observational Model: Family-Based
Time Perspective: Prospective
Not Provided
Retention:   Samples With DNA
blood samples and subcutaneous tissue
Non-Probability Sample
patients in Denmark operated or diagnosed with hernias who are member of a family with tendency to hernias.
Not Provided
  • control group
  • individuals from hernia-family
Not Provided

*   Includes publications given by the data provider as well as publications identified by Identifier (NCT Number) in Medline.
Unknown status
Same as current
June 2011
December 2010   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • adults over 18 years
  • adults must be members of a family where there are presence of hernias in minimum generation.

Exclusion Criteria:

  • infections
  • pregnant
  • mentally ill patients
Sexes Eligible for Study: All
18 Years and older   (Adult, Older Adult)
Contact information is only displayed when the study is recruiting subjects
Not Provided
Not Provided
Jakob Burcharth, MD., Herlev Hospital, Department of surgical Gastroenterology
Herlev Hospital
Not Provided
Study Director: Jacob Rosenberg, Prof. MD Herlev Hospital
Principal Investigator: Jakob Burcharth, MD Herlev Hospital
Herlev Hospital
October 2010