Aerobic Exercise to Improve Executive Language Function In Older Adults

This study has been completed.
Information provided by (Responsible Party):
Department of Veterans Affairs Identifier:
First received: September 15, 2009
Last updated: November 13, 2014
Last verified: November 2014

September 15, 2009
November 13, 2014
September 2010
January 2012   (final data collection date for primary outcome measure)
Executive Language Functions [ Time Frame: number of correct words at pre and post separated by 12 weeks ] [ Designated as safety issue: No ]
The Verbal Fluency Test is demonstrated to be reliable and valid among adults aged 50 to 89 (Delis, et al., 2001; Delis, Kramer, Kaplan, & Hodnack, 2004). The Verbal Fluency Test has three conditions, Letter Verbal Fluency, Category Verbal Fluency, and Switching Verbal Fluency. Each was randomized at pre- and post-12 week timeline and equated for difficulty. Letter Verbal Fluency assesses the number of words beginning with certain letters that participants can generate within 60 seconds,the Category Verbal Fluency assesses the number of words within particular categories participants can generate within 60 seconds, and the Switching Verbal Fluency assesses the number of words while alternating between different categories participants can generate within 60 seconds. For each condition (letter, category, and switching) a total score representing the total number of correct
Executive Language Functions [ Time Frame: pre and post seperated by 12 weeks ] [ Designated as safety issue: No ]
Complete list of historical versions of study NCT00979069 on Archive Site
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Aerobic Exercise to Improve Executive Language Function In Older Adults
Aerobic Exercise to Improve Executive Language Function in Older Adults

The purpose of this study is to see if exercise can improve brain function in older adults

Recently, considerable attention has been devoted to examining the beneficial relationship between cognition and aerobic exercise in older adults. Specifically, the effects are thought to involve higher order cognitive processes, such as working memory, switching between tasks, and inhibiting irrelevant information, all of which are thought to be sub- served, in part, by the frontal lobes (Colcombe et al., 2006). Importantly, these areas also are most susceptible to age-related decline (Raz, 2000) and are essential resources for language production (Kemper & Sumner, 2001; Murray & Lenz, 2001). However, despite promising cognitive improvement, changes in frontally-mediated executive language functions have been widely ignored. This is unfortunate considering impaired word retrieval compromises communicative effectiveness, leading to frustration, depression, and withdrawal. Perhaps more importantly, communication ineffectiveness, particularly in the elderly, leads to difficulties interacting with health care professionals leading to further health care burdens. Since cognition, and specifically word retrieval difficulties, usually remain untreated, it is important to find treatment strategies for minimizing these deficits. Therefore, the short-term goal and the purpose of this proposal is to examine the potential of aerobic exercise to improve executive language function in older adults.

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Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
Behavioral: Aerobic group
12 weeks of aerobic exercise 3 times a week
  • Experimental: Aerobic Group
    12 weeks of aerobic exercise 3 times a week
    Intervention: Behavioral: Aerobic group
  • No Intervention: Control Group
    No contact control
Nocera JR, McGregor KM, Hass CJ, Crosson B. Spin exercise improves semantic fluency in previously sedentary older adults. J Aging Phys Act. 2015 Jan;23(1):90-4. doi: 10.1123/japa.2013-0107. Epub 2014 Jan 14.

*   Includes publications given by the data provider as well as publications identified by Identifier (NCT Number) in Medline.
January 2012
January 2012   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Consent of participants' primary health care physicians to participate in the aerobic exercise.
  • Patients must not have participated in any consistent exercise program or experimental study for at least 3 months prior to enrollment.
  • They must be capable of providing informed consent and complying with the trial procedures.

Exclusion Criteria:

  • Demented as defined by the Modified Mini Mental Status Exam.
  • Unalterable travel schedules.
  • Site accessibility constraints.
65 Years to 89 Years
Contact information is only displayed when the study is recruiting subjects
United States
Department of Veterans Affairs
Department of Veterans Affairs
Not Provided
Principal Investigator: Joe R Nocera, PhD Atlanta VA Medical and Rehab Center, Decatur, GA
Department of Veterans Affairs
November 2014

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP