Vitamin D Supplementation for the Prevention of Acute Respiratory Tract Infections

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00973583
Recruitment Status : Completed
First Posted : September 9, 2009
Last Update Posted : December 3, 2014
Finnish Defense Forces
Information provided by (Responsible Party):
Ilkka Laaksi, University of Tampere

September 8, 2009
September 9, 2009
December 3, 2014
May 2005
December 2009   (Final data collection date for primary outcome measure)
Number of days absent from duty due to respiratory tract infection [ Time Frame: 6 months ]
Same as current
Complete list of historical versions of study NCT00973583 on Archive Site
  • The proportion of men remaining healthy throughout the 6-month study period [ Time Frame: 6 months ]
  • The number needed to treat calculated from the proportion of men without any days absent from duty [ Time Frame: 6 months ]
Same as current
Not Provided
Not Provided
Vitamin D Supplementation for the Prevention of Acute Respiratory Tract Infections
Vitamin D Supplementation for the Prevention of Acute Respiratory Tract Infections; a Randomized Double-blinded Trial in Young Finnish Men
The investigators earlier clinical study in 754 young Finnish men demonstrated a significant negative association of serum 25-OHD concentration with acute respiratory tract infections. The present study aimed to determine whether vitamin D supplementation may decrease the incidence of acute respiratory tract infections.
Subjects comprised 164 male conscripts at a military base in Finland. Half of the participants were randomly allocated to receive 400 IU vitamin D daily and half received placebo from October through March. Serum vitamin D and plasma parathyroid hormone concentrations were determined. Subjects were followed for 6 months and the primary outcome was the number of days absent from duty due to ARTI.
Not Applicable
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary Purpose: Prevention
Respiratory Tract Infections
  • Dietary Supplement: vitamin D
    vitamin D3 400 IU daily
    Other Name: Minisun
  • Dietary Supplement: placebo
    Other Name: Pharmia, Finland
  • Active Comparator: vitamin D
    Intervention: Dietary Supplement: vitamin D
  • Placebo Comparator: placebo
    Intervention: Dietary Supplement: placebo
Not Provided

*   Includes publications given by the data provider as well as publications identified by Identifier (NCT Number) in Medline.
Same as current
December 2010
December 2009   (Final data collection date for primary outcome measure)

Inclusion Criteria:

Exclusion Criteria:

  • Use vitamin D
Sexes Eligible for Study: Male
Child, Adult, Senior
Contact information is only displayed when the study is recruiting subjects
Not Provided
Not Provided
Ilkka Laaksi, University of Tampere
University of Tampere
Finnish Defense Forces
Principal Investigator: Ilkka T Laaksi, M.D. University of Tampere
Study Director: Harri Pihlajamaki, Docent Research Department, Centre for Military Medicine, Helsinki, Finland
University of Tampere
December 2014

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP