Language Treatment for Progressive Aphasia

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00957710
Recruitment Status : Completed
First Posted : August 12, 2009
Last Update Posted : January 27, 2015
Canadian Institutes of Health Research (CIHR)
Information provided by (Responsible Party):
Regina Jokel, Baycrest

August 11, 2009
August 12, 2009
January 27, 2015
August 2009
July 2010   (Final data collection date for primary outcome measure)
Accuracy of picture naming [ Time Frame: 3 months ]
Same as current
Complete list of historical versions of study NCT00957710 on Archive Site
Changes on neuroimaging [ Time Frame: 3 months ]
Same as current
Not Provided
Not Provided
Language Treatment for Progressive Aphasia
Slowing Language Decline in Progressive Aphasia Through Language Rehabilitation: Treatment and Neuroimaging Study
Progressive aphasia is characterized by a steady and progressive loss of language skills in the presence of relatively preserved memory, attention, and thinking. The aim of this study is to slow the progression of language decline in progressive aphasia via language therapy. The first goal of this study is to improve naming abilities of individuals with progressive aphasia. This will be accomplished by carrying out an intensive treatment program for anomia. The second goal is to evaluate whether this intense language treatment re-activates affected areas and/or connections within the language network, using functional Magnetic Resonance Imaging (to measure neural activity in specific brain regions) and Diffusion Tensor Imaging tractography (to measure the connectivity between specific brain regions). This is the first study on progressive aphasia addressing both treatment and imaging in the same patients.
Not Provided
Not Applicable
Intervention Model: Single Group Assignment
Masking: None (Open Label)
  • Primary Progressive Aphasia
  • Nonfluent Progressive Aphasia
  • Semantic Dementia
Behavioral: Errorless learning
Language testing,20 sessions of language therapy, and 2 neuroimaging sessions for participants with progressive aphasia Language testing and 1 imaging session for healthy controls
Other Name: treatment for anomia
langauge therapy
Naming therapy
Intervention: Behavioral: Errorless learning

*   Includes publications given by the data provider as well as publications identified by Identifier (NCT Number) in Medline.
December 2010
July 2010   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • Diagnosis of progressive aphasia
  • Native English speaker or fluent in English
  • Adequate hearing and vision (not requiring more than +6 diopter correction)
  • Willing and able to participate in each phase of the study (including two fMRI sessions)

Exclusion Criteria:

  • Contraindications to fMRI (e.g., claustrophobia, pacemaker, ferromagnetic implant)
  • Current medical or psychiatric condition affecting cognition (other than progressive aphasia)
Sexes Eligible for Study: All
40 Years to 80 Years   (Adult, Older Adult)
Contact information is only displayed when the study is recruiting subjects
REB 09-24
Not Provided
Not Provided
Regina Jokel, Baycrest
Canadian Institutes of Health Research (CIHR)
Principal Investigator: Regina Jokel, PhD Baycrest
January 2015

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP