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Effects of Obstructive Sleep Apnea and/or Cigarette Smoking on Endothelial Function

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00957463
First Posted: August 12, 2009
Last Update Posted: December 30, 2014
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
The University of Hong Kong
August 10, 2009
August 12, 2009
December 30, 2014
June 2008
December 2011   (Final data collection date for primary outcome measure)
reactive hyperemia induced peripheral arterial tone (RH-RAT) index [ Time Frame: baseline ]
Same as current
Complete list of historical versions of study NCT00957463 on ClinicalTrials.gov Archive Site
circulatory metabolic and vascular inflammatory biomarkers [ Time Frame: baseline ]
Same as current
Not Provided
Not Provided
 
Effects of Obstructive Sleep Apnea and/or Cigarette Smoking on Endothelial Function
Effects of Intermittent Hypoxia and/or Cigarette Smoking on Endothelial Injury in Vivo - Relevance to Obstructive Sleep Apnea
The hypothesis of this study is that either obstructive sleep apnea (OSA) or cigarette smoking (CS) exposure would produce oxidative stress and inflammation leading to endothelial injury, and the combined exposure would be additive or synergistic.
Not Provided
Observational
Observational Model: Case Control
Time Perspective: Cross-Sectional
Not Provided
Not Provided
Non-Probability Sample
Consecutive subjects who undergo polysomnograms (PSG) in the Sleep Disorder Centre, Department of Medicine, Queen Mary Hospital, and who fulfill the study criteria will be recruited.
  • Obstructive Sleep Apnea
  • Smoking
Not Provided
  • smoker, with high apnea-hypopnea index
    subjects who smoke either in the past or currently, with confirmed moderate-severe OSA
  • smoker, mild OSA or without OSA
    subjects who smoke either in the past or currently, with mild OSA or without OSA
  • nonsmoker, with high apnea-hypopnea index
    subjects who never smoke, with confirmed moderate-severe OSA
  • nonsmoker, with mild OSA or without OSA
    subjects who never smoke, with mild OSA or without OSA

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
150
Not Provided
December 2011   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • No acute illness
  • No hospitalization in past 4 weeks
  • Absence of medical comorbidity such as hypertension, ischemic heart disease, diabetes and hyperlipidemia, renal impairment, vasculitis or Raynaud's syndrome, peripheral vascular disease especially Buerger's disease, aortic disease (aortic aneurysm or dilatation), cancer, thrombocytopenia, coagulation disorder or other chronic medical illness

Exclusion Criteria:

  • Mentally incapacitated
Sexes Eligible for Study: All
18 Years and older   (Adult, Senior)
No
Contact information is only displayed when the study is recruiting subjects
Hong Kong
 
 
NCT00957463
UW 08-023
Not Provided
Not Provided
Not Provided
Professor Mary SM Ip, The University of Hong Kong
The University of Hong Kong
Not Provided
Principal Investigator: Mary SM Ip, MD The University of Hong Kong
The University of Hong Kong
December 2014