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Effects of Pistachios on Cardiovascular Responses to Stress in Type 2 Diabetes (Pistachio)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
ClinicalTrials.gov Identifier: NCT00956735
Recruitment Status : Completed
First Posted : August 11, 2009
Last Update Posted : December 16, 2013
Information provided by (Responsible Party):

August 10, 2009
August 11, 2009
December 16, 2013
August 2009
March 2013   (Final data collection date for primary outcome measure)
  • Cardiovascular responses to stress [ Time Frame: End of each diet period ]
  • Insulin sensitivity and resistance [ Time Frame: End of each diet period ]
  • Lipids and lipoproteins [ Time Frame: End of each diet period ]
Cardiovascular responses to stress [ Time Frame: 10-14 weeks ]
Complete list of historical versions of study NCT00956735 on ClinicalTrials.gov Archive Site
  • Vascular endothelial function [ Time Frame: End of each diet period ]
  • Mood and perceived stress [ Time Frame: End of each diet period ]
Not Provided
Not Provided
Not Provided
Effects of Pistachios on Cardiovascular Responses to Stress in Type 2 Diabetes
Effects of Pistachios on Cardiovascular Responses to Stress in Type 2 Diabetes: A Novel Intervention for a High Risk Population
This study is investigating the effects of three different diets, including a diet with pistachios, on cardiovascular disease risk markers in people with type 2 diabetes.
The study will last 12-16 weeks and requires 10-13 visits to the General Clinical Research Center on the University Park campus. All food and snacks will be provided for 10 weeks. At the end of each of three diet periods, participants will undergo a test of endothelial function, an oral glucose tolerance test, and a cardiovascular stress reactivity test.
Not Provided
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single (Outcomes Assessor)
Primary Purpose: Basic Science
  • Cardiovascular Disease
  • Type 2 Diabetes
Other: Pistachio
3.0 oz (2 servings) of roasted and salted or unsalted pistachios
  • Experimental: Pistachio Diet
    Incorporates 3.0 oz (2 servings) of pistachios into a daily diet
    Intervention: Other: Pistachio
  • No Intervention: Non-Pistachio
    Does not incorporate pistachios into a daily diet

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
March 2013
March 2013   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • Healthy, nonsmoking adults, aged 30-75 years (women must be post-menopausal)
  • Diagnosed with Type 2 diabetes

Exclusion Criteria:

  • Insulin, more than one blood pressure lowering medication, daily aspirin, NSAID therapy, oral steroids within the last 6 weeks, oral contraceptives, and hormone replacement therapy
  • Chronic disease such as cardiovascular disease or any complications of diabetes (retinopathy, neuropathy, etc).
  • Allergies or aversions to pistachios
  • Unwillingness to consume all foods provided and no other meals or snacks for the 10 weeks of diet intervention
Sexes Eligible for Study: All
30 Years to 75 Years   (Adult, Senior)
Contact information is only displayed when the study is recruiting subjects
United States
Not Provided
Not Provided
Sheila G West, Penn State University
Penn State University
American Pistachio Growers
Principal Investigator: Sheila G. West, PhD Penn State University
Penn State University
December 2013

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP