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Etiology, Epidemiology and Prognostics of Acute Kidney Injury (AKI)

This study is currently recruiting participants.
Verified August 2017 by Feng Ding,MD, Huashan Hospital
Sponsor:
ClinicalTrials.gov Identifier:
NCT00953992
First Posted: August 6, 2009
Last Update Posted: August 31, 2017
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.
Collaborator:
Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Information provided by (Responsible Party):
Feng Ding,MD, Huashan Hospital
August 5, 2009
August 6, 2009
August 31, 2017
April 2009
December 2017   (Final data collection date for primary outcome measure)
renal function survival rate days in the hospital days in the ICU [ Time Frame: discharg from hospital, 28days,90days ]
Same as current
Complete list of historical versions of study NCT00953992 on ClinicalTrials.gov Archive Site
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Etiology, Epidemiology and Prognostics of Acute Kidney Injury (AKI)
The Study of Etiology, Epidemiology and Prognostic Factors of Acute Kidney Injury
  • To investigate the etiology, epidemiology and prognostic factors of acute kidney injury.
  • To find out risk factors that relate with the prognosis of acute kidney injury,focusing on inflammation, oxidative stress and nutritional status.
  • To study on the relationship between gene polymorphism and prognosis of acute kidney injury.
  1. to investigate the relationship between preexisting malnutrition and adverse outcomes in patients with AKI

    - Several nutritional assessment methods such as anthropometric, clinical and biochemical evaluations have been used; however, no single indicator is considered to be a "gold standard."

  2. to evaluate the association of serum nutritional variables and prognosis of acute kidney injury
  3. Given the different half-lives of serum nutritional markers, we hypothesized that the utility of serum nutritional variables as prognostic predictors may differ in early death (<7 days) and late death (>7 days, <28 days) patients.
Observational
Observational Model: Cohort
Time Perspective: Prospective
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Retention:   Samples Without DNA
Description:
1ml whole blood and 1ml serum will obtained within 24 hour after AKI for hematological and biochemistry analyze.
Non-Probability Sample
Patients selected from a university-affiliated hospital in Shanghai, China.
  • Renal Failure
  • Nutrition Disorders
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
600
December 2018
December 2017   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • age >=16 years and <= 88 years
  • clinically diagnosed with acute kidney injury, according RIFLE or KDIGO criteria.

Exclusion Criteria:

  • acute Renal Failure occurring in the setting of burns, obstructive uropathy, allergic interstitial nephritis, acute or rapidly progressive glomerulonephritis, vasculitis, hemolytic-uremic syndrome, thrombotic thrombocytopenic purpura (TTP), malignant hypertension, scleroderma renal crisis, atheroembolism, functional or surgical nephrectomy, hepatorenal syndrome, cyclosporin or tacrolimus nephrotoxicity
  • Do Not Resuscitate (DNR) status
  • subjects enrolled in another clinical trial that could affect the outcome of this study protocol
Sexes Eligible for Study: All
16 Years to 88 Years   (Child, Adult, Senior)
No
Contact: Feng Ding, professor 86-02152888135 dingfeng@sjtu.edu.cn
China
 
 
NCT00953992
KY2009-107
Yes
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Feng Ding,MD, Huashan Hospital
Huashan Hospital
Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Principal Investigator: Feng Ding, professor Huashan Hospital
Huashan Hospital
August 2017