Concurrent Treatment for Depressed Parents and DepressedAdolescents

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00951821
Recruitment Status : Completed
First Posted : August 4, 2009
Results First Posted : August 31, 2015
Last Update Posted : August 31, 2015
National Institute of Mental Health (NIMH)
Information provided by (Responsible Party):
Anthony Spirito, Brown University

August 3, 2009
August 4, 2009
February 20, 2015
August 31, 2015
August 31, 2015
July 2009
December 2013   (Final data collection date for primary outcome measure)
Beck Depression Inventory - Adolescent Report, Change in Symptom Level [ Time Frame: 12 months ]
self-report measure of depressed mood - range of scores 0 to 60; higher scores indicate worse depression. The data in this outcome refer to change from baseline to 12 month follow-up, per the adolescent self-report.
Depression [ Time Frame: Measured at baseline, post-treatment, and after 12 months ]
Complete list of historical versions of study NCT00951821 on Archive Site
Beck Suicide Scale - Adolescent Response [ Time Frame: Measured at 12 months ]
measure of suicidal ideation - scale ranges from 0 to 38 - higher scores indicate higher suicidal ideation. These data refer to adolescent respondents. The outcome is a change score so range is from -38 to 38.
Suicidal ideation and behavior [ Time Frame: Measured at baseline, post-treatment, and after 12 months ]
Not Provided
Not Provided
Concurrent Treatment for Depressed Parents and DepressedAdolescents
Concurrent Treatment for Parents and Adolescents Who Attempt Suicide
This study will develop an integrated treatment for adolescents who are depressed and suicidal and their parents who are depressed and have a history of suicidality.

Depression, like many psychiatric disorders, has a genetic component that makes it more likely that members of the same family will have the disorder. Depression in parents, particularly mothers, may put the children at greater risk for depression. When an adolescent whose parent is depressed develops depression himself or herself, treating both the parent and the adolescent may be more effective than treating only the adolescent. This study will test a depression treatment that targets depressed suicidal adolescents with a parent or primary caretaker who is also depressed and has a history of suicidality.

Participation in this study will last 6 months. Participants will be randomly assigned to receive either concurrent parent and adolescent treatment or adolescent only treatment. For those assigned to concurrent treatment, both the adolescent participants and one of their parents will receive individual cognitive behavioral therapy (CBT) counseling sessions and joint family counseling sessions. In the adolescent only treatment condition, adolescent participants will receive individual CBT sessions, but parents will not, and both will receive joint family sessions. Counseling sessions will last 1 hour and occur weekly for 3 months, and then every other week for 3 months. CBT identifies and attempts to change problematic thought patterns. All participants will receive medication consultation if necessary.

Participants will complete assessments at baseline, post-treatment, and 6 months after completing treatment. These assessments will include questionnaires and interviews about depression, suicidal thoughts, mood regulation, behavioral problems, and family. At post-treatment and the 6-month follow-up, participants will also be asked to give feedback about the counseling, medication consultation, and their satisfaction.

Not Applicable
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary Purpose: Treatment
  • Depression
  • Suicide
  • Behavioral: Concurrent treatment
    Individual CBT sessions for parents and adolescents plus combined parent-adolescent family sessions, delivered weekly for 3 months in the acute phase and bimonthly for 3 months in the maintenance phase. The techniques used to teach cognitive restructuring and problem solving to parents will be similar to those taught to the adolescents, except emotion regulation skills will be added to the parent treatment.
    Other Name: CBT for adolescents and parents
  • Behavioral: Adolescent treatment only
    Individual CBT for adolescents only plus combined parent-adolescent family sessions, delivered weekly for 3 months in the acute phase and bimonthly for 3 months in the maintenance phase
  • Experimental: Concurrent treatment
    Concurrent treatment - experimental condition: Adolescent participants and their parents will receive concurrent cognitive behavioral therapy.
    Intervention: Behavioral: Concurrent treatment
  • Active Comparator: Adolescent treatment only
    Adolescent treatment only - Active Comparator: Only adolescent participants will receive cognitive behavioral therapy.
    Intervention: Behavioral: Adolescent treatment only
Not Provided

*   Includes publications given by the data provider as well as publications identified by Identifier (NCT Number) in Medline.
December 2013
December 2013   (Final data collection date for primary outcome measure)

Inclusion Criteria for Adolescents:

  • Lives at home with at least one parent or guardian
  • Speaks English
  • Must have made a suicide attempt and be diagnosed with major depressive disorder (MDD)

Inclusion Criteria for Primary Caretakers:

  • Speaks English
  • Current diagnosis of MDD and a history of suicidality

Exclusion Criteria for Adolescents:

  • Judged to have developmental or cognitive delays or psychotic disorders on the basis of a standard psychiatric exam
  • Diagnosis of bipolar disorder or a substance dependence (people with a diagnosis of substance abuse are eligible)
  • Only one adolescent per family is eligible

Exclusion Criteria for Primary Caretakers:

  • Diagnosis of bipolar disorder or substance dependence
  • If taking antidepressants, not on a stable dose for 3 months
Sexes Eligible for Study: All
12 Years to 17 Years   (Child)
Contact information is only displayed when the study is recruiting subjects
United States
R34MH082211( U.S. NIH Grant/Contract )
R34MH082211 ( U.S. NIH Grant/Contract )
Not Provided
Not Provided
Anthony Spirito, Brown University
Brown University
National Institute of Mental Health (NIMH)
Principal Investigator: Anthony Spirito, PhD Brown University
Brown University
March 2015

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP