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Evaluation of Alteration by Magnetic Resonance Imaging (MRI) in Dementia Among Elderly Subjects (AMIMAGE)

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ClinicalTrials.gov Identifier: NCT00951197
Recruitment Status : Completed
First Posted : August 4, 2009
Last Update Posted : April 30, 2012
Sponsor:
Information provided by (Responsible Party):
University Hospital, Bordeaux

April 22, 2009
August 4, 2009
April 30, 2012
April 2009
March 2011   (Final data collection date for primary outcome measure)
FA (Fractional Anisotropy), MTR (magnetization transfer ratio) and T2 (Transverse relaxation time) measures in patients with dementia compared to controls, in left and right hippocampus, and posterior cingulum [ Time Frame: day 0 ]
FA (Fractional Anisotropy), MTR (magnetization transfer ratio) and T2 (Transverse relaxation time) measures in patients with dementia compared to controls, in left and right hippocampus, and Cingulate cortex [ Time Frame: day 0 ]
Complete list of historical versions of study NCT00951197 on ClinicalTrials.gov Archive Site
  • FA, MTR and T2 measures in subjects with mild cognitive impairment no dementia [ Time Frame: day 0 ]
  • Performances in the 7 neuropsychological tests available in the AMI cohort [ Time Frame: day 0 ]
  • FA measures for the connexion Hippocampus-cingulum posterior [ Time Frame: day 0 ]
  • FA, MTR and T2 measures in subjects with mild cognitive impairment no demented [ Time Frame: day 0 ]
  • Performances in the 7 neuropsychological tests available in the AMI cohort [ Time Frame: day 0 ]
  • FA measures for the connexion Hippocampus-cingulum posterior [ Time Frame: day 0 ]
Not Provided
Not Provided
 
Evaluation of Alteration by Magnetic Resonance Imaging (MRI) in Dementia Among Elderly Subjects
Estimation of Microstructure Alteration by MRI in Dementia Among Elderly Subjects Retired From Agricultural Profession and Living in Rural Area in Gironde - Participants From the AMI Cohort.
Capturing the earliest stages of Dementia especially Alzheimer's Disease (AD) is a great challenge. Until now the NINCDS-ADRDA and the DSM criteria for AD were largely used as diagnostic standards in research. However, the research on AD progresses and some biomarkers have been recently suggested to improve the diagnostic criteria of AD, such as cerebrospinal fluid markers, neuroimaging with Positon Emission Tomography (PET) or Magnetic Resonance Imaging (MRI).
Not Provided
Observational
Observational Model: Ecologic or Community
Time Perspective: Prospective
Not Provided
Not Provided
Non-Probability Sample
population retired from agricultural profession and living in rural area in Gironde
  • Dementia
  • Alzheimer Disease
Other: Neuroimaging
Three successive MRI acquisitions to measure FA, MTR and T2 parameters.
elderly subjects retired from agriculture
Intervention: Other: Neuroimaging
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
318
400
March 2011
March 2011   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • participate in the AMI cohort
  • be aged 65 and older
  • be retired from agricultural profession
  • live in rural area in Gironde

Exclusion Criteria:

  • contraindication of MRI
  • left-handed
  • severe dementia
  • Parkinson's disease
  • poor health incompatible with the transport to neuroimaging service
  • to be left handed
Sexes Eligible for Study: All
65 Years and older   (Older Adult)
No
Contact information is only displayed when the study is recruiting subjects
France
 
 
NCT00951197
CHUBX2008/13
No
Not Provided
Not Provided
University Hospital, Bordeaux
University Hospital, Bordeaux
Not Provided
Principal Investigator: Michèle ALLARD University Hospital, Bordeaux
University Hospital, Bordeaux
April 2012