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A Study of Lymphangiogenesis in Colorectal and Nasopharyngeal Cancer

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified January 2014 by National University Hospital, Singapore.
Recruitment status was:  Active, not recruiting
Sponsor:
ClinicalTrials.gov Identifier:
NCT00943891
First Posted: July 22, 2009
Last Update Posted: January 22, 2014
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
National University Hospital, Singapore
July 20, 2009
July 22, 2009
January 22, 2014
July 2008
December 2014   (Final data collection date for primary outcome measure)
Not Provided
Not Provided
Complete list of historical versions of study NCT00943891 on ClinicalTrials.gov Archive Site
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A Study of Lymphangiogenesis in Colorectal and Nasopharyngeal Cancer
A Study of Lymphangiogenesis in Colorectal and Nasopharyngeal Cancer
  1. To determine the association between LVD and clinico-pathologic variables in archived colorectal cancer and Nasopharyngeal carcinoma specimens
  2. To determine the association between VEGF-C,-D expression with COX-2 expression and clinico-pathologic variables in colorectal cancer and Nasopharyngeal carcinoma
  3. To determine the effect of celecoxib on lymphangiogenesis in Nasopharyngeal carcinoma Lymphangiogenesis and factors modulating lymphangiogenesis are associated with clinico-pathological outcome in Nasopharyngeal carcinoma and colorectal cancer. Celecoxib down-regulates lymphangiogenesis Archival colorectal cancer and Nasopharyngeal carcinoma tumor specimens will be obtained from the Department of Pathology. To determine the effect of celecoxib on lymphangiogenesis in Nasopharyngeal carcinoma, the investigators intend to analyze archived specimens collected in a previously conducted study. Colorectal tumor and nodal specimens and Nasopharyngeal carcinoma primary will be examined for MVD, LVD and growth factor expression using established haematoxylin and eosin and immunohistochemical techniques. Quantification of LVD and MVD shall be performed by two pathologists blinded to clinico-pathological variables using standardised methods.
Not Provided
Observational
Observational Model: Case-Crossover
Time Perspective: Cross-Sectional
Not Provided
Retention:   Samples With DNA
Description:
CRC and NPC tumor specimens will be obtained.
Non-Probability Sample
Colorectal and nasopharyngeal cancer.
  • Colorectal Cancer
  • Nasopharyngeal Cancer
Procedure: Tumor biopsies
Tumor biopsies
Intervention: Procedure: Tumor biopsies

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Unknown status
500
December 2014
December 2014   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • Male and female patients are eligible
  • Patients 21 years or older

Exclusion Criteria:

Sexes Eligible for Study: All
21 Years and older   (Adult, Senior)
No
Contact information is only displayed when the study is recruiting subjects
Singapore
 
 
NCT00943891
MC01/09/08
No
Not Provided
Not Provided
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National University Hospital, Singapore
Not Provided
Principal Investigator: Ross Andrew Soo, MBBS National University Hospital, Singapore
National University Hospital, Singapore
January 2014