Natriuretic Peptides - Predictors of In-hospital and Long-term Major Adverse Cardiac Events After Emergency Surgery?

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Medical University of Graz
ClinicalTrials.gov Identifier:
NCT00942786
First received: July 18, 2009
Last updated: June 9, 2015
Last verified: June 2015

July 18, 2009
June 9, 2015
February 2008
January 2014   (final data collection date for primary outcome measure)
Occurence of Adverse Cardiac Events [ Time Frame: postoperatively (index surgery) until a median follow-up of 34 months ] [ Designated as safety issue: Yes ]

Occurence of major adverse cardiac events (composite of nonfatal myocardial infarction, acute heart failure or death).

Non-fatal Myocardial infarction was defined as a typical increase and decrease of troponin together with evidence of myocardial ischemia with at least one of the following: symptoms of ischemia, ECG changes indicative of ischemia or new Q waves, or imaging evidence of new regional wall motion abnormality.

Acute heart failure was defined as clinical signs and symptoms of heart failure with echocardiographic evidence of cardiac dysfunction and clinical response to treatment directed towards heart failure.

Major adverse cardiac event [ Time Frame: in-hospital and during 1 year follow-up ] [ Designated as safety issue: Yes ]
Complete list of historical versions of study NCT00942786 on ClinicalTrials.gov Archive Site
Not Provided
Not Provided
  • NT-ProBNP Preoperative [ Time Frame: 0-24 hours before induction of anesthesia ] [ Designated as safety issue: No ]
    NT-ProBNP was measured 0-24 hours before induction of anesthesia
  • Association Between Preoperative NT-ProBNP and Occurence of Adverse Cardiac Events [ Time Frame: postoperatively (index surgery) until a median follow-up of 34 months ] [ Designated as safety issue: No ]
    Evaluation of the association between preoperative NT-ProBNP and occurence of adverse cardiac events
Not Provided
 
Natriuretic Peptides - Predictors of In-hospital and Long-term Major Adverse Cardiac Events After Emergency Surgery?
Prospective Study to Evaluate the Predictive Value of Brain Natriuretic Peptides for Adverse Long-term Cardiac Outcome

The investigators hypothesize that the level of perioperative natriuretic peptides is associated with in-hospital and long term major adverse cardiac events.

The purpose of the study is to measure levels of brain natriuretic peptides before and after urgent non-cardiac surgery and to evaluate their predictive value for adverse long-term outcome.

Observational
Observational Model: Cohort
Time Perspective: Prospective
Not Provided
Retention:   Samples Without DNA
Description:

one vial of serum per patient is retained

Non-Probability Sample

Consecutive patients undergoing emergency non-cardiac surgery

Surgery
Not Provided
No treatment
Consecutive patients undergoing emergency surgery
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
297
February 2014
January 2014   (final data collection date for primary outcome measure)

Inclusion criteria:

  • Emergency surgery:

    1. Vascular
    2. Intra-abdominal
    3. Orthopedic

      Exclusion Criteria:

  • Patients unable to provide informed consent
  • Thoracic surgery
  • Trauma surgery
Both
50 Years and older
No
Contact information is only displayed when the study is recruiting subjects
Austria
 
NCT00942786
19-077 ex 07/08
Yes
Medical University of Graz
Medical University of Graz
Not Provided
Principal Investigator: Elisabeth Mahla, M.D. Department of Anesthesiology and Intensive Care Medicine, Medical University of Graz
Medical University of Graz
June 2015

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP