NON-Invasive Examinations of Coronary Artery Disease (NONCAD)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00926458
Recruitment Status : Unknown
Verified June 2009 by Herning Hospital.
Recruitment status was:  Recruiting
First Posted : June 23, 2009
Last Update Posted : June 23, 2009
Information provided by:
Herning Hospital

June 22, 2009
June 23, 2009
June 23, 2009
January 2009
January 2012   (Final data collection date for primary outcome measure)
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No Changes Posted
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NON-Invasive Examinations of Coronary Artery Disease
NON-Invasive Examinations of Coronary Artery Disease
The aim of the study is to evaluate and compare the value of 5 different non-invasive diagnostic methods in patients with chest pain suspected for coronary artery disease. The investigators intend to include 200 patients over a 3 year period in the study. The participants will be recruited from patients referred to coronary angiography at the institution. Before the angiography the participants will (1) test the effect of sublingual Nitroglycerin, (2) give their medical history so mathematical models can estimate the probability of the presence of coronary artery disease, (3) take part in a contrast stress echocardiography and (4) a 2D-strain stress echocardiography and a myocardial scintigraphy. Stenosis found at the angiography will be the gold standard.

The aim of the study is to evaluate the diagnostic value of various non-invasive methods. The study is divided into five substudies:

Substudy NITRO

Purpose: To investigate whether a subjective effect of Nitroglycerine is associated with significantly narrowed coronary arteries.

The participants are instructed to alternate between rest and Nitroglycerine as treatment for chest pain attacks during a 2 week period. Chest pain score is recorded in a diary handed out at day 1 together with 30 tablets Nitroglycerine in the maximal tolerated dose.

Substudy SCORE

Aim: To test and compare the ability of different statistical methods using clinical data to predict the presence of narrowed coronary arteries in a contemporary Danish population.


Aim: To evaluate if the blood flow in an area in the heart muscle measured by contrast adenosine stress echocardiography can predict the presence of significant stenosis in the coronary artery supplying the area.

Substudy 2D strain

Aim: To Evaluate if lack of increase in 2D strain during adenosine stress echocardiography can predict the presence of narrowed coronary arteries.

Substudy SPECT

Aim: To evaluate whether the result of a myocardial scintigraphy can predict symptomatic chest pain relief 6 months after a coronary angiography and possible treatment with balloon or bypass surgery.

Participants: Annually around 1,500 coronary angiographies are performed at Region Hospital Herning. We intend to include 200 patients referred by their physicians to coronary angiography in the study and expect the data collection phase to last 3 years.

Observational Model: Cohort
Time Perspective: Prospective
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Non-Probability Sample
All patients referred for coronary angiography at Region Hospital Herning are screened for the study and all patients complying with the in-/exclusion criteria are invited to participate in the study.
Coronary Artery Disease
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*   Includes publications given by the data provider as well as publications identified by Identifier (NCT Number) in Medline.
Unknown status
Same as current
January 2012
January 2012   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  1. Intermittent episodes of chest pain (more than two attacks, minimum one attack/week)
  2. Signed written informed consent
  3. Sinus rhythm (ECG)
  4. Age above 18 years

Exclusion Criteria:

  1. Previously (known) myocardial infarction or unstable angina with dynamic changes in the ECG or biomarkers (serology)
  2. CA performed earlier in life
  3. Known significant cardiac valve disease
  4. Asthma (not COPD)
  5. Incapable of performing an exercise test
  6. Malignant Disease
  7. Senile dementia or other conditions causing impaired cooperation
  8. Previous participation in the project
  9. NTG intolerance
  10. Pregnancy
  11. Bundle branch block (QRS > 120 ms)
  12. ECG changes:

    • Pathologic Q-wave in at least two leads:
    • QS-complex or Q-wave > 0.02 sec. in V2-V3
    • QS-complex or Q-wave > 0.03 sec. and > 0.1 mV in I, II, aVL, aVF or V4-V6
    • Pathologic negative T-wave (in V3-6 and I, II) unless this is part of a left ventricular hypertrophy and strain pattern
  13. Brady pacemaker
Sexes Eligible for Study: All
18 Years and older   (Adult, Senior)
Contact information is only displayed when the study is recruiting subjects
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Ole May, Cardiovascular Research Unit, Region Hospital Herning
Herning Hospital
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Principal Investigator: Ole May, MD, Ph.D. Cardiovascular Research Unit
Herning Hospital
June 2009