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Collection of Blood From Patients With Prostate Cancer

This study is currently recruiting participants.
Verified September 27, 2017 by National Institutes of Health Clinical Center (CC) ( National Cancer Institute (NCI) )
Sponsor:
ClinicalTrials.gov Identifier:
NCT00923221
First Posted: June 18, 2009
Last Update Posted: October 19, 2017
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.
Information provided by (Responsible Party):
National Institutes of Health Clinical Center (CC) ( National Cancer Institute (NCI) )
June 17, 2009
June 18, 2009
October 19, 2017
March 1, 2007
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Acquisition and longitudinal analysis of genomic DNA from patients with prostate cancer to aid in understanding the mechanisms of prostate carcinogenesis and progression [ Time Frame: Study duration ]
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Complete list of historical versions of study NCT00923221 on ClinicalTrials.gov Archive Site
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Collection of Blood From Patients With Prostate Cancer
Collection of Blood From Patients With Prostate Cancer

Background:

  • It is not fully understood why prostate cancer in some men becomes androgen-independent (no longer responds to anti-androgen medication), but genetics likely plays an important role.
  • Genes contain the hereditary information that is passed down from parents to children. Although everyone has the same set of genes, individuals can have different forms of the same gene.
  • Differences in genes may explain, at least in part, why some people develop a more aggressive form of prostate cancer than others.

Objectives:

-To obtain blood samples from patients with prostate cancer to try to identify gene differences associated with progression to the androgen independent state.

Eligibility:

-All patients participating in NCI prostate cancer protocols.

Design:

  • Patients with prostate cancer are evaluated in the NCI s Medical Oncology Clinic.
  • Blood samples are collected at the initial visit or at follow-up visits.
  • DNA (genetic material) and white blood cells are extracted from these samples to be used for genotyping and establishment of cell lines.
  • Gene variations are correlated with prostate cancer prognosis and prognostic indicators.

Objectives:

To obtain blood samples from patients with prostate cancer for genotyping analyses.

Eligibility:

All patients seen in the NCI prostate cancer clinic are eligible.

Design:

Patients with a prior diagnosis of prostate cancer will be evaluated in the GMB Clinic, NCI. Blood samples may be collected at the initial visit or at follow-up visits. Genomic DNA and white blood cells will each be extracted from these samples to be utilized for genotyping and establishment of individual cell lines. Genetic variance will be correlated with prostate cancer prognosis (i.e. time from diagnosis to death) and prognostic indicators (i.e. histological tumor grade). Healthy controls will not be compared and no correlations will be made with prostate cancer susceptibility.

Observational
Observational Model: Case-Only
Time Perspective: Cross-Sectional
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Prostatic Neoplasms
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
1000
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  • INCLUSION CRITERIA:

Patients 18 years of age and older are eligible.

Patients with a diagnosis of prostate cancer are eligible.

EXCLUSION CRITERIA:

Children are not eligible.

Sexes Eligible for Study: Male
18 Years to 100 Years   (Adult, Senior)
No
Contact: William D Figg, Pharm.D. (240) 760-6179 wdfigg@helix.nih.gov
United States
 
 
NCT00923221
070100
07-C-0100
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National Institutes of Health Clinical Center (CC) ( National Cancer Institute (NCI) )
National Cancer Institute (NCI)
Not Provided
Principal Investigator: William D Figg, Pharm.D. National Cancer Institute (NCI)
National Institutes of Health Clinical Center (CC)
September 27, 2017