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Collecting and Storing Blood and Brain Tumor Tissue Samples From Children With Brain Tumors

This study is currently recruiting participants. (see Contacts and Locations)
Verified November 2016 by Children's Oncology Group
Sponsor:
Collaborator:
National Cancer Institute (NCI)
Information provided by (Responsible Party):
Children's Oncology Group
ClinicalTrials.gov Identifier:
NCT00919750
First received: June 11, 2009
Last updated: November 21, 2016
Last verified: November 2016

June 11, 2009
November 21, 2016
March 2005
January 2100   (final data collection date for primary outcome measure)
  • Collection of brain tumor tissue and an accompanying blood sample from pediatric patients with brain tumors treated at Children's Oncology Group institutions [ Time Frame: Up to 16 years ] [ Designated as safety issue: No ]
  • Creation of a repository for long-term storage of these specimens [ Time Frame: Up to 16 years ] [ Designated as safety issue: No ]
  • Making these specimens available to qualified researchers to understand the biology of pediatric brain tumors [ Time Frame: Up to 16 years ] [ Designated as safety issue: No ]
  • Collection of brain tumor tissue and an accompanying blood sample from pediatric patients with brain tumors treated at Children's Oncology Group institutions [ Designated as safety issue: No ]
  • Creation of a repository for long-term storage of these specimens [ Designated as safety issue: No ]
  • Making these specimens available to qualified researchers to understand the biology of pediatric brain tumors [ Designated as safety issue: No ]
Complete list of historical versions of study NCT00919750 on ClinicalTrials.gov Archive Site
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Collecting and Storing Blood and Brain Tumor Tissue Samples From Children With Brain Tumors
A Children's Oncology Group Protocol for Collecting and Banking Pediatric Brain Tumor Research Specimens
The purpose of this study is to collect and store brain tissue samples and blood from children with brain cancer that will be tested in the laboratory. Collecting and storing samples of tumor tissue and blood from patients to test in the laboratory may help the study of cancer in the future.

OBJECTIVES:

I. Collect brain tumor tissue and an accompanying blood sample from pediatric patients with brain tumors treated at Children's Oncology Group institutions.

II. Provide a repository for long-term storage of specimens from these patients.

III. Make these specimens available to qualified researchers to understand the biology of pediatric brain tumors.

OUTLINE: This is a multicenter study.

Brain tumor tissue and blood specimens are collected from patients and banked for future study.

Observational
Observational Model: Case-Only
Time Perspective: Prospective
Not Provided
Retention:   Samples With DNA
Description:
brain tumor tissue, blood
Non-Probability Sample
All patients treated for a brain tumor at a COG institution are eligible for participation in this study.
  • Childhood Atypical Teratoid/Rhabdoid Tumor
  • Childhood Central Nervous System Germ Cell Tumor
  • Childhood Choroid Plexus Tumor
  • Childhood Craniopharyngioma
  • Childhood Grade I Meningioma
  • Childhood Grade II Meningioma
  • Childhood Grade III Meningioma
  • Childhood High-grade Cerebral Astrocytoma
  • Childhood Infratentorial Ependymoma
  • Childhood Low-grade Cerebral Astrocytoma
  • Childhood Oligodendroglioma
  • Childhood Supratentorial Ependymoma
  • Newly Diagnosed Childhood Ependymoma
  • Recurrent Childhood Cerebellar Astrocytoma
  • Recurrent Childhood Cerebral Astrocytoma
  • Recurrent Childhood Ependymoma
  • Recurrent Childhood Medulloblastoma
  • Recurrent Childhood Supratentorial Primitive Neuroectodermal Tumor
  • Recurrent Childhood Visual Pathway and Hypothalamic Glioma
  • Recurrent Childhood Visual Pathway Glioma
Other: cytology specimen collection procedure
Correlative studies
Other Name: cytologic sampling
Ancillary-Correlative (tissue and blood sample collection)
Brain tumor tissue and blood specimens are collected from patients and banked for future study. There are no sample size goals for this protocol and no projected closing date.
Intervention: Other: cytology specimen collection procedure
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
5000
Not Provided
January 2100   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Diagnosis of brain tumor
  • Previously treated at a Children's Oncology Group (COG) institution

    • Patients are eligible at time of diagnosis, second-look surgery, recurrence, or development of a second malignant neoplasm
  • Must have brain tumor biological specimens derived from primary tumors of the CNS available for submission
Both
up to 18 Years   (Child, Adult)
No
United States,   Australia,   Canada,   New Zealand,   Puerto Rico,   Switzerland
 
NCT00919750
ACNS02B3, NCI-2009-00334, COG-ACNS02B3, CDR0000352347, ACNS02B3, ACNS02B3, U10CA098543
No
Not Provided
Not Provided
Children's Oncology Group
Children's Oncology Group
National Cancer Institute (NCI)
Principal Investigator: Scott Pomeroy Children's Oncology Group
Children's Oncology Group
November 2016

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP