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Hepatic Mitochondrial Function in Sepsis

The recruitment status of this study is unknown because the information has not been verified recently.
Verified June 2011 by Institut d'Anesthesiologie des Alpes Maritimes.
Recruitment status was  Recruiting
Information provided by:
Institut d'Anesthesiologie des Alpes Maritimes Identifier:
First received: April 24, 2009
Last updated: June 30, 2011
Last verified: June 2011

April 24, 2009
June 30, 2011
April 2009
April 2012   (final data collection date for primary outcome measure)
Mitochondrial complex activities [ Time Frame: during surgery ] [ Designated as safety issue: No ]
Same as current
Complete list of historical versions of study NCT00889083 on Archive Site
  • Quantification of adenine nucleotides [ Time Frame: during surgery ] [ Designated as safety issue: No ]
  • Quantification of oxidative stress markers [ Time Frame: during surgery ] [ Designated as safety issue: No ]
  • Correlation between SOFA score and mitochondrial complex activities [ Time Frame: 28 days ] [ Designated as safety issue: No ]
Same as current
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Hepatic Mitochondrial Function in Sepsis
Evaluation of Hepatic Mitochondrial Function in Sepsis

Multi-organ failure due to sepsis is a major cause of death in critically ill patients. But the mechanisms leading to this condition are not fully understood. Mitochondrial dysfunction has been shown in skeletal muscle of critically ill septic patients. Liver is very important in sepsis as it is responsible of the synthesis of several inflammatory proteins. Moreover hepatic failure is associated to a bad outcome.

The aim of this study is to evaluate the hepatic mitochondrial function in sepsis.

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Observational Model: Case Control
Time Perspective: Prospective
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Retention:   Samples With DNA
Liver biopsies
Non-Probability Sample
Community sample
  • Sepsis
  • Peritonitis
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  • Control
    Non septic patients needing hepatic surgery
  • Sepsis
    Septic patients needing surgery for peritonitis

*   Includes publications given by the data provider as well as publications identified by Identifier (NCT Number) in Medline.
April 2012
April 2012   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Septic group : Peritonitis patients needing surgery
  • Non septic group : Patients needing hepatic surgery

Exclusion Criteria:

  • No liver biopsy performed
18 Years to 80 Years   (Adult, Senior)
Contact: Jean-Christophe Orban, MD 0033611947008
Contact: Carole Ichai, MD, PhD
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Jean-Christophe Orban, CHU de Nice
Institut d'Anesthesiologie des Alpes Maritimes
Not Provided
Study Chair: Carole Ichai, MD, PhD CHU de Nice
Institut d'Anesthesiologie des Alpes Maritimes
June 2011

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP