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Hepatic Mitochondrial Function in Sepsis

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified June 2011 by Institut d'Anesthesiologie des Alpes Maritimes.
Recruitment status was:  Recruiting
Sponsor:
ClinicalTrials.gov Identifier:
NCT00889083
First Posted: April 28, 2009
Last Update Posted: July 4, 2011
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
Institut d'Anesthesiologie des Alpes Maritimes
April 24, 2009
April 28, 2009
July 4, 2011
April 2009
April 2012   (Final data collection date for primary outcome measure)
Mitochondrial complex activities [ Time Frame: during surgery ]
Same as current
Complete list of historical versions of study NCT00889083 on ClinicalTrials.gov Archive Site
  • Quantification of adenine nucleotides [ Time Frame: during surgery ]
  • Quantification of oxidative stress markers [ Time Frame: during surgery ]
  • Correlation between SOFA score and mitochondrial complex activities [ Time Frame: 28 days ]
Same as current
Not Provided
Not Provided
 
Hepatic Mitochondrial Function in Sepsis
Evaluation of Hepatic Mitochondrial Function in Sepsis

Multi-organ failure due to sepsis is a major cause of death in critically ill patients. But the mechanisms leading to this condition are not fully understood. Mitochondrial dysfunction has been shown in skeletal muscle of critically ill septic patients. Liver is very important in sepsis as it is responsible of the synthesis of several inflammatory proteins. Moreover hepatic failure is associated to a bad outcome.

The aim of this study is to evaluate the hepatic mitochondrial function in sepsis.

Not Provided
Observational
Observational Model: Case Control
Time Perspective: Prospective
Not Provided
Retention:   Samples With DNA
Description:
Liver biopsies
Non-Probability Sample
Community sample
  • Sepsis
  • Peritonitis
Not Provided
  • Control
    Non septic patients needing hepatic surgery
  • Sepsis
    Septic patients needing surgery for peritonitis

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Unknown status
60
April 2012
April 2012   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • Septic group : Peritonitis patients needing surgery
  • Non septic group : Patients needing hepatic surgery

Exclusion Criteria:

  • No liver biopsy performed
Sexes Eligible for Study: All
18 Years to 80 Years   (Adult, Senior)
No
Contact information is only displayed when the study is recruiting subjects
France
 
 
NCT00889083
IAAM-2009-1
No
Not Provided
Not Provided
Jean-Christophe Orban, CHU de Nice
Institut d'Anesthesiologie des Alpes Maritimes
Not Provided
Study Chair: Carole Ichai, MD, PhD CHU de Nice
Institut d'Anesthesiologie des Alpes Maritimes
June 2011