Discard:Characterisation of Colonic Polyps in Vivo (DISCARD)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00888771
Recruitment Status : Completed
First Posted : April 28, 2009
Last Update Posted : February 12, 2016
Information provided by (Responsible Party):
Imperial College London

April 27, 2009
April 28, 2009
February 12, 2016
August 2008
February 2009   (Final data collection date for primary outcome measure)
Accuracy of polyp characterisation [ Time Frame: 12 months ]
Same as current
Complete list of historical versions of study NCT00888771 on Archive Site
Change in surveillance interval after formal histopathology [ Time Frame: 12 months ]
Same as current
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Discard:Characterisation of Colonic Polyps in Vivo
Characterisation of Small Colonic Polyps in Vivo
Prospective study of accuracy of colonic polyp characterisation in vivo using high resolution white light endoscopy, narrow band imaging and chromoendoscopy.
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Observational Model: Cohort
Time Perspective: Prospective
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Non-Probability Sample
The study group therefore would comprise those presenting for 3 yearly follow up or sooner i.e. those with a resected colorectal cancer or those with ≥ three adenomas or one advanced ≥10mm adenoma or those with a positive faecal occult blood test
Colorectal Polyps
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Ignjatovic A, East JE, Suzuki N, Vance M, Guenther T, Saunders BP. Optical diagnosis of small colorectal polyps at routine colonoscopy (Detect InSpect ChAracterise Resect and Discard; DISCARD trial): a prospective cohort study. Lancet Oncol. 2009 Dec;10(12):1171-8. doi: 10.1016/S1470-2045(09)70329-8. Epub 2009 Nov 10.

*   Includes publications given by the data provider as well as publications identified by Identifier (NCT Number) in Medline.
Same as current
June 2009
February 2009   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  1. Patients over 18 years of age, assessed as fit for routine colonoscopy
  2. Patients attending for screening or surveillance colonoscopy meeting the following criteria:

    • Polyp surveillance with at least 3 adenomas or 1 adenoma>10mm at previous colonoscopy
    • Surveillance post colorectal cancer resection
    • Screening with positive faecal occult blood test

Exclusion Criteria:

  1. Patients with known colitis or polyposis syndromes
  2. Unable or unwilling to give informed consent
Sexes Eligible for Study: All
18 Years and older   (Adult, Older Adult)
Contact information is only displayed when the study is recruiting subjects
United Kingdom
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Imperial College London
Imperial College London
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Principal Investigator: Brian P Saunders, MD Wolfson Unit for Endoscopy, St Mark's Hospital
Imperial College London
July 2010