|First Submitted Date||April 18, 2009|
|First Posted Date||April 21, 2009|
|Last Update Posted Date||July 2, 2017|
|Start Date||April 15, 2009|
|Primary Completion Date||Not Provided|
|Current Primary Outcome Measures
||The outcome measures will be (a) graded changes in blood oxygen level-dependent (BOLD) in response to motor learning and reward and (b) variations in GABA concentration in response to motor learning and reward.|
|Original Primary Outcome Measures||Not Provided|
|Change History||Complete list of historical versions of study NCT00885131 on ClinicalTrials.gov Archive Site|
|Current Secondary Outcome Measures
||The secondary outcome measures will be variations in response time in the behavioral performance of a learning task.|
|Original Secondary Outcome Measures||Not Provided|
|Current Other Outcome Measures||Not Provided|
|Original Other Outcome Measures||Not Provided|
|Brief Title||Effect of Reward on Learning in Motor Cortex|
|Official Title||Effects of Reward on Learning in the Motor Cortex|
Objective: The role of mesencephalic dopamine neurons in reward processing has been established in primates using electrophysiological techniques and in humans using functional neuroimaging. They have rich projections to both the prefrontal and motor cortices where they synapse on interneurons and cortical pyramidal cells, producing primarily inhibition. Though their function is not fully understood, these projections clearly play an important role in motivation and learning. We recently developed a paradigm to detect reward-related signals in the primary motor cortex, using transcranial magnetic stimulation (TMS), and demonstrated increased inhibition in primary motor cortex under conditions of increased reward expectancy. These results suggest that motor learning, which depends critically on the motor cortex, may be influenced by reward, which may take the form of simple performance feedback in humans. This kind of feedback also allows subjects to predict the outcome of actions. Thus, our present objective is to investigate the influence of reward/feedback/prediction on the activity of primary motor cortex during motor learning and in particular during instances of increased reward expectancy. Further, we will examine the role of a brain derived neurotrophic factor (BDNF) single nucleotide polymorphism on motor learning.
Study Population: The population that we will study will be healthy volunteers between the ages of 18-50, without any significant medical history or contraindication to functional magnetic resonance imaging (fMRI).
Design: All experiments will employ within- or between-subjects fMRI and magnetic resonance spectroscopy (MRS) to measure changes in activations of different cortical areas in response to motor learning and reward.
Outcome Measures: The outcome measures will be (a) graded changes in blood oxygen level-dependent (BOLD) in response to motor learning and reward and (b) variations in GABA concentration in response to motor learning and reward, and c) variations in response time in the behavioral performance of a learning task.
|Study Design||Time Perspective: Prospective|
|Target Follow-Up Duration||Not Provided|
|Sampling Method||Not Provided|
|Study Population||Not Provided|
|Study Groups/Cohorts||Not Provided|
* Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
|Estimated Completion Date||January 22, 2013|
|Primary Completion Date||Not Provided|
|Ages||18 Years to 50 Years (Adult)|
|Accepts Healthy Volunteers||No|
|Contacts||Contact information is only displayed when the study is recruiting subjects|
|Listed Location Countries||United States|
|Removed Location Countries|
|Other Study ID Numbers||090124
|Has Data Monitoring Committee||Not Provided|
|U.S. FDA-regulated Product||Not Provided|
|IPD Sharing Statement||Not Provided|
|Responsible Party||Not Provided|
|Study Sponsor||National Institute of Neurological Disorders and Stroke (NINDS)|
|PRS Account||National Institutes of Health Clinical Center (CC)|
|Verification Date||January 22, 2013|