Early Detection of Arteriosclerosis

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00863967
Recruitment Status : Unknown
Verified March 2009 by Kantonsspital Baselland Bruderholz.
Recruitment status was:  Active, not recruiting
First Posted : March 18, 2009
Last Update Posted : March 18, 2009
Information provided by:
Kantonsspital Baselland Bruderholz

March 17, 2009
March 18, 2009
March 18, 2009
October 2003
October 2015   (Final data collection date for primary outcome measure)
Cardiovascular events [ Time Frame: 10 years at least ]
Same as current
No Changes Posted
Disease activity score [ Time Frame: 2 / 5 / 10 years ]
Same as current
Not Provided
Not Provided
Early Detection of Arteriosclerosis
Prospective Observational Cohort Study for Early Detection of Arteriosclerosis

Arteriosclerosis is a common chronic disease with well known risk factors like diabetes mellitus, hypertension, dyslipidemia, adipositas and smoking, leading to severe complications like myocardial infarction, stroke or peripheral arterial occlusive disease. In addition to life-style factors there is also a genetic predisposition to develop complicated atherosclerosis.

Objective: Improve individual risk prediction by clinical phenotyping and genotyping.

About 300 patients who are treated for various conditions at the department of general medicine at our hospital will be included prospectively in the study. This observational cohort will be followed for at least 10 years follow-up examinations.

At baseline and during follow up visits detailed clinical phenotyping is planned (medical and family history,standardized clinical and physical examinations, lab, RX, ECG, stress-test or echocardiogram). The genotyping is performed by DNA-isolation from leucocytes collected at baseline.

Observational Model: Cohort
Time Perspective: Prospective
Not Provided
Retention:   Samples With DNA
Whole blood / serum / white cells / plasma
Probability Sample
teaching hospital primary care clinic
  • Arteriosclerosis
  • Atherosclerosis
  • Myocardial Infarction
  • Stroke
  • Diabetes Mellitus
  • Peripheral Arterial Occlusive Disease
Not Provided
  • 1
    no cardiovascular events
  • 2
    proven cardiovascular events
  • 3
    possible cardiovascular events

*   Includes publications given by the data provider as well as publications identified by Identifier (NCT Number) in Medline.
Unknown status
Same as current
October 2015
October 2015   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • 18 years and older
  • informed consent

Exclusion Criteria:

  • life-threatening disease
  • life expectancy < 1 month
  • uncapable to provide informed consent
Sexes Eligible for Study: All
18 Years and older   (Adult, Older Adult)
Contact information is only displayed when the study is recruiting subjects
Not Provided
KSBH: 216/03
Not Provided
Not Provided
Barbara Biedermann MD, Department of medicine, Kantonsspital Bruderholz, CH-4101 Bruderholz
Kantonsspital Baselland Bruderholz
Not Provided
Principal Investigator: Barbara Biedermann, MD Medical Department Kantonsspital Bruderholz CH-4101 Bruderholz
Kantonsspital Baselland Bruderholz
March 2009