Now Available: Final Rule for FDAAA 801 and NIH Policy on Clinical Trial Reporting

Early Detection of Arteriosclerosis

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified March 2009 by Kantonsspital Baselland Bruderholz.
Recruitment status was:  Active, not recruiting
Sponsor:
Information provided by:
Kantonsspital Baselland Bruderholz
ClinicalTrials.gov Identifier:
NCT00863967
First received: March 17, 2009
Last updated: NA
Last verified: March 2009
History: No changes posted

March 17, 2009
March 17, 2009
October 2003
October 2015   (final data collection date for primary outcome measure)
Cardiovascular events [ Time Frame: 10 years at least ] [ Designated as safety issue: No ]
Same as current
No Changes Posted
Disease activity score [ Time Frame: 2 / 5 / 10 years ] [ Designated as safety issue: No ]
Same as current
Not Provided
Not Provided
 
Early Detection of Arteriosclerosis
Prospective Observational Cohort Study for Early Detection of Arteriosclerosis

Arteriosclerosis is a common chronic disease with well known risk factors like diabetes mellitus, hypertension, dyslipidemia, adipositas and smoking, leading to severe complications like myocardial infarction, stroke or peripheral arterial occlusive disease. In addition to life-style factors there is also a genetic predisposition to develop complicated atherosclerosis.

Objective: Improve individual risk prediction by clinical phenotyping and genotyping.

About 300 patients who are treated for various conditions at the department of general medicine at our hospital will be included prospectively in the study. This observational cohort will be followed for at least 10 years follow-up examinations.

At baseline and during follow up visits detailed clinical phenotyping is planned (medical and family history,standardized clinical and physical examinations, lab, RX, ECG, stress-test or echocardiogram). The genotyping is performed by DNA-isolation from leucocytes collected at baseline.

Observational
Observational Model: Cohort
Time Perspective: Prospective
Not Provided
Retention:   Samples With DNA
Description:
Whole blood / serum / white cells / plasma
Probability Sample
teaching hospital primary care clinic
  • Arteriosclerosis
  • Atherosclerosis
  • Myocardial Infarction
  • Stroke
  • Diabetes Mellitus
  • Peripheral Arterial Occlusive Disease
Not Provided
  • 1
    no cardiovascular events
  • 2
    proven cardiovascular events
  • 3
    possible cardiovascular events

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Unknown status
269
October 2015
October 2015   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • 18 years and older
  • informed consent

Exclusion Criteria:

  • life-threatening disease
  • life expectancy < 1 month
  • uncapable to provide informed consent
Both
18 Years and older   (Adult, Senior)
No
Contact information is only displayed when the study is recruiting subjects
Not Provided
 
NCT00863967
KSBH: 216/03
No
Not Provided
Not Provided
Barbara Biedermann MD, Department of medicine, Kantonsspital Bruderholz, CH-4101 Bruderholz
Kantonsspital Baselland Bruderholz
Not Provided
Principal Investigator: Barbara Biedermann, MD Medical Department Kantonsspital Bruderholz CH-4101 Bruderholz
Kantonsspital Baselland Bruderholz
March 2009

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP