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Gene Expression Profiling in Subjects With Postoperative Atrial Fibrillation After Cardiac Surgery

This study is currently recruiting participants.
Verified May 2017 by Simon Body, Brigham and Women's Hospital
Sponsor:
ClinicalTrials.gov Identifier:
NCT00833313
First Posted: February 2, 2009
Last Update Posted: May 16, 2017
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.
Information provided by (Responsible Party):
Simon Body, Brigham and Women's Hospital
January 5, 2009
February 2, 2009
May 16, 2017
August 2008
August 2018   (Final data collection date for primary outcome measure)
Gene expression [ Time Frame: Immediate ]
Same as current
Complete list of historical versions of study NCT00833313 on ClinicalTrials.gov Archive Site
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Not Provided
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Gene Expression Profiling in Subjects With Postoperative Atrial Fibrillation After Cardiac Surgery
Gene Expression Profiling in Subjects With Postoperative Atrial Fibrillation After Cardiac Surgery
Atrial fibrillation is a type of irregular heartbeat that is common after having heart surgery. There may be many different reasons why some people get atrial fibrillation after their heart surgery. These reasons may include that a person is older or that he/she is taking certain types of medications before surgery. Genes may also be a reason. Genes contain the material passed from parent to child that determines the make-up of the body and mind. For example, some genes control the color of your hair or eyes. Some people may have genes that make it more likely for them to get atrial fibrillation after their heart surgery. This research project is being done to find out if the cells of people who develop atrial fibrillation after heart surgery are different from the cells in people who do not develop atrial fibrillation after surgery.

Atrial fibrillation is a type of irregular heartbeat that is common after having heart surgery. There may be many different reasons why some people get atrial fibrillation after their heart surgery. These reasons may include that a person is older or that he/she is taking certain types of medications before surgery. Genes may also be a reason. Genes contain the material passed from parent to child that determines the make-up of the body and mind. For example, some genes control the color of your hair or eyes. Some people may have genes that make it more likely for them to get atrial fibrillation after their heart surgery. This research project is being done to find out if the cells of people who develop atrial fibrillation after heart surgery are different from the cells in people who do not develop atrial fibrillation after surgery.

This study seeks to identify regulatory events in atrial myocyte transcription and translation that are altered by germline variation

Observational
Observational Model: Cohort
Time Perspective: Prospective
Not Provided
Retention:   Samples With DNA
Description:
Atrial tissue sample
Non-Probability Sample
Adult patients undergoing cardiac surgery
Atrial Fibrillation
Other: Atrial biopsy
Biopsy of right atrial free wall
Not Provided
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
240
August 2018
August 2018   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • Age 20-80 years
  • Undergoing cardiac surgery

Exclusion Criteria:

  • Prior atrial fibrillation or flutter
  • Taking Amiodarone
  • Taking Sotalol
Sexes Eligible for Study: All
20 Years to 80 Years   (Adult, Senior)
No
Contact: Simon C Body, MD 617-732-7330 sbody@partners.org
United States
 
 
NCT00833313
2008-P000896
No
Not Provided
Not Provided
Simon Body, Brigham and Women's Hospital
Brigham and Women's Hospital
Not Provided
Principal Investigator: Simon C Body, MD Brigham and Women's Hospital
Brigham and Women's Hospital
May 2017