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Observation of Initial Procalcitonin and the Clinical Course of Patients With Acute Respiratory Tract Infections

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00827060
First Posted: January 22, 2009
Last Update Posted: January 28, 2009
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
Hannover Medical School
January 21, 2009
January 22, 2009
January 28, 2009
December 2006
June 2007   (Final data collection date for primary outcome measure)
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Not Provided
Complete list of historical versions of study NCT00827060 on ClinicalTrials.gov Archive Site
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Observation of Initial Procalcitonin and the Clinical Course of Patients With Acute Respiratory Tract Infections
Observation of the Initial Procalcitonin Values and the Clinical Course of Patients With Acute Respiratory Tract Infections at General Medical Practices in Greater Hannover
Observation of the initial Procalcitonin values and the clinical course of consecutively included patients with Acute Respiratory Tract Infections at general medical practices in greater Hannover.

Primary endpoint:

  • initial Procalcitonin values of patients with Acute Respiratory Tract Infections

Secondary endpoints:

  • correlation of initial Procalcitonin values to classify Acute Respiratory Tract Infections
  • correlation of initial Procalcitonin values to subjective severity of Acute Respiratory Tract Infections
  • correlation of initial Procalcitonin values to antibiotic- prescriptions
  • correlation of initial Procalcitonin values to frequency of admission to hospital
  • correlation of initial Procalcitonin values to frequency of referrals (radiology, pneumology)
Observational
Observational Model: Case-Only
Time Perspective: Prospective
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Probability Sample
primary care patients in 45 practices in greater Hannover
Respiratory Tract Infections
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Burkhardt O, Ewig S, Haagen U, Giersdorf S, Hartmann O, Wegscheider K, Hummers-Pradier E, Welte T. Procalcitonin guidance and reduction of antibiotic use in acute respiratory tract infection. Eur Respir J. 2010 Sep;36(3):601-7. doi: 10.1183/09031936.00163309. Epub 2010 Feb 25.

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
702
September 2007
June 2007   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • written informed consent
  • all types of respiratory tract infection according to investigator´s diagnosis

Exclusion Criteria:

  • pretreatment with antibiotics in the past 2 weeks
  • portal hypertension
  • Major surgeries or multiple trauma which require hospitalization, in previous 4 weeks
  • Autoimmune disease and systemic diseases (lupus erythematodes, wegener´s disease)
  • Peritoneal dialysis
  • Acute treated or recently operated medullary c-cell-carcinoma, SCLC, carcinoid
  • Other inflammatory diseases (e.g. urinary tract infection, pyelonephritis, pancreatitis
Sexes Eligible for Study: All
18 Years and older   (Adult, Senior)
No
Contact information is only displayed when the study is recruiting subjects
Germany
 
 
NCT00827060
HannoverPro
No
Not Provided
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Prof. Dr. med. Tobias Welte
Hannover Medical School
Not Provided
Principal Investigator: Olaf Burkhardt, PD Dr. med. Medical School Hannover
Hannover Medical School
January 2009