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Carotid Ultrasound in the Evaluation of Heart Failure (CUE-HF)

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Harmony R. Reynolds, New York University School of Medicine
ClinicalTrials.gov Identifier:
NCT00810550
First received: December 17, 2008
Last updated: April 5, 2016
Last verified: April 2016

December 17, 2008
April 5, 2016
October 2005
December 2008   (final data collection date for primary outcome measure)
Diagnostic accuracy for severe CAD [ Time Frame: 1 Day ] [ Designated as safety issue: No ]
Diagnostic accuracy for severe CAD
Complete list of historical versions of study NCT00810550 on ClinicalTrials.gov Archive Site
Diagnostic accuracy for significant CAD [ Time Frame: 1 Day ] [ Designated as safety issue: No ]
Diagnostic accuracy for significant CAD
Not Provided
Not Provided
 
Carotid Ultrasound in the Evaluation of Heart Failure
Carotid Ultrasound in the Evaluation of Heart Failure
Coronary artery disease (CAD, cholesterol plaque buildup in the heart arteries) is the most common cause of left ventricular systolic dysfunction (weakening of the heart muscle). The standard test to find coronary artery disease is coronary angiography. This test is highly accurate but is invasive and carries a small risk of complications. This study investigates ultrasound of the carotid (neck) arteries as a screening test for severe coronary artery disease as a cause of left ventricular systolic dysfunction. It is hypothesized that carotid ultrasound will have excellent negative predictive value for severe CAD.
Coronary artery disease (CAD, cholesterol plaque buildup in the heart arteries) is the most common cause of left ventricular systolic dysfunction (weakening of the heart muscle). The standard test to find coronary artery disease is coronary angiography. This test is highly accurate but is invasive and carries a small risk of complications. This study investigates ultrasound of the carotid (neck) arteries as a screening test for severe coronary artery disease as a cause of left ventricular systolic dysfunction. It is hypothesized that carotid ultrasound will have excellent negative predictive value for severe CAD.
Interventional
Not Provided
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Diagnostic
  • Coronary Artery Disease
  • Cardiomyopathy
  • Heart Failure
Other: Carotid ultrasound
Measurement of intima-media thickness
LV systolic dysfunction
Diagnostic Testing
Intervention: Other: Carotid ultrasound
Reynolds HR, Steckman DA, Tunick PA, Kronzon I, Lobach I, Rosenzweig BP. Normal intima-media thickness on carotid ultrasound reliably excludes an ischemic cause of cardiomyopathy. Am Heart J. 2010 Jun;159(6):1059-66. doi: 10.1016/j.ahj.2010.03.026.

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
150
December 2008
December 2008   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • LVEF 40% or less

Exclusion Criteria:

  • Prior diagnosis of coronary or carotid obstructive atherosclerosis
Both
18 Years to 99 Years   (Adult, Senior)
No
Contact information is only displayed when the study is recruiting subjects
Not Provided
 
NCT00810550
NYCC CUE-HF
No
Not Provided
Not Provided
Harmony R. Reynolds, New York University School of Medicine
New York University School of Medicine
Not Provided
Not Provided
New York University School of Medicine
April 2016

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP