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Performance of CAST (Cellular Antigen Stimulation Test) in Patients With Wasp Venom Allergy: Evaluation of Neutralizing IgG Subclasses

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ClinicalTrials.gov Identifier: NCT00794287
Recruitment Status : Withdrawn
First Posted : November 20, 2008
Last Update Posted : June 4, 2015
Sponsor:
Information provided by:
University of Zurich

Tracking Information
First Submitted Date November 19, 2008
First Posted Date November 20, 2008
Last Update Posted Date June 4, 2015
Study Start Date January 2009
Estimated Primary Completion Date December 2010   (Final data collection date for primary outcome measure)
Current Primary Outcome Measures Not Provided
Original Primary Outcome Measures Not Provided
Change History Complete list of historical versions of study NCT00794287 on ClinicalTrials.gov Archive Site
Current Secondary Outcome Measures Not Provided
Original Secondary Outcome Measures Not Provided
Current Other Pre-specified Outcome Measures Not Provided
Original Other Pre-specified Outcome Measures Not Provided
 
Descriptive Information
Brief Title Performance of CAST (Cellular Antigen Stimulation Test) in Patients With Wasp Venom Allergy: Evaluation of Neutralizing IgG Subclasses
Official Title Performance of CAST (Cellular Antigen Stiumulation Test)in Patients With Wasp Venom Allergy. Evaluation of Neutralizing IgG Subclasses
Brief Summary To determine which subclass of IgG in the serum of patients undergoing SIT against wasp venom is able to neutralize the allergen, and therefore to prevent a positive CAST
Detailed Description Not Provided
Study Type Observational
Study Design Observational Model: Cohort
Time Perspective: Retrospective
Target Follow-Up Duration Not Provided
Biospecimen Retention:   Samples Without DNA
Description:
Blood samples
Sampling Method Probability Sample
Study Population Wasp venom allergic patients grade III and IV according to H.L. Müller in the age group of 18-75 years
Condition Wasp Venom Allergic Patients
Intervention Other: Taking blood samples
No intervention is done. Only blood samples are taken.
Study Groups/Cohorts
  • 1
    Hymenoptera allergic patients before allergen specific immunotherapy
    Intervention: Other: Taking blood samples
  • 2
    Hymenoptera allergic patients after allergen specific immunotherapy
    Intervention: Other: Taking blood samples
Publications * Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruitment Information
Recruitment Status Withdrawn
Actual Enrollment
 (submitted: June 3, 2015)
0
Original Estimated Enrollment
 (submitted: November 19, 2008)
20
Study Completion Date Not Provided
Estimated Primary Completion Date December 2010   (Final data collection date for primary outcome measure)
Eligibility Criteria

Inclusion criteria:

  • male and female patient with allergy to wasp venom grade III and IV according to H.L. Müller
  • 18-75 years
  • planned SIT against wasp venom or finished 5 years SIT against wsp venom (10/10)

Exclusion criteria:

  • oral corticosteroids
  • chromogycin
  • ketotifen
  • immunosuppressive drugs within the last 2 years
Sex/Gender
Sexes Eligible for Study: All
Ages 18 Years to 75 Years   (Adult, Older Adult)
Accepts Healthy Volunteers No
Contacts Contact information is only displayed when the study is recruiting subjects
Listed Location Countries Switzerland
Removed Location Countries  
 
Administrative Information
NCT Number NCT00794287
Other Study ID Numbers ZU-AgNT-004
Has Data Monitoring Committee Yes
U.S. FDA-regulated Product Not Provided
IPD Sharing Statement Not Provided
Responsible Party PD Dr. Thomas Kündig, University of Zurich
Study Sponsor University of Zurich
Collaborators Not Provided
Investigators
Study Director: 01 Studienregister MasterAdmins UniversitaetsSpital Zuerich
PRS Account University of Zurich
Verification Date June 2015