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Imaging Cardiac Electrical Remodeling With Electrocardiogram Imaging (ECGI)

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified November 2008 by Washington University School of Medicine.
Recruitment status was:  Recruiting
Sponsor:
ClinicalTrials.gov Identifier:
NCT00785564
First Posted: November 5, 2008
Last Update Posted: November 5, 2008
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
Washington University School of Medicine
November 3, 2008
November 5, 2008
November 5, 2008
November 2007
November 2009   (Final data collection date for primary outcome measure)
ECGI Image [ Time Frame: 1 month after RV pacing ]
Same as current
No Changes Posted
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Imaging Cardiac Electrical Remodeling With Electrocardiogram Imaging (ECGI)
Imaging Cardiac Electrical Remodeling With ECGI
A consequence of chronic RV pacing is a process of electrical remodeling that alters myocardial repolarization to reflect the altered depolarization induced by the RV lead. When RV pacing is discontinued, the altered repolarization persists for several weeks. This phenomena is traditionally described as "T-wave memory" based upon the 12-lead ECG appearance of inverted T-Waves. The investigators are using the ECGI technique to produce three dimensional electroanatomical images of this phenomena in patients with dual chamber pacemakers. Echocardiography will also be used to image the mechanical effects of RV pacing and T-wave memory. The images will show the spatial distribution of altered repolarization and allow us to correlate any mechanical consequences of this phenomena that may exist.
Not Provided
Observational
Observational Model: Cohort
Time Perspective: Prospective
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Non-Probability Sample
Patients of a pacemaker clinic
Sick Sinus Syndrome
Not Provided
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Unknown status
10
November 2009
November 2009   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • Implanted dual chamber pacemaker for sick sinus syndrome with no history of complete heart block.

Exclusion Criteria:

  • Persistent atrial fibrillation that is not suppressed by medications.
Sexes Eligible for Study: All
18 Years and older   (Adult, Senior)
No
Contact information is only displayed when the study is recruiting subjects
United States
 
 
NCT00785564
07-0995
No
Not Provided
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Mitchell N. Faddis MD, PhD, Washington University School of Medicine
Washington University School of Medicine
Not Provided
Principal Investigator: Mitchell N Faddis, MD PhD Washington University School of Medicine
Washington University School of Medicine
November 2008