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Intravenous Metoprolol Versus Intravenous Amiodarone in the Prevention of Atrial Fibrillation After Cardiac Surgery

This study has been completed.
Sponsor:
Collaborators:
Tampere University Hospital
Vaasa Central Hospital, Vaasa, Finland
Information provided by (Responsible Party):
Jari Halonen, Kuopio University Hospital
ClinicalTrials.gov Identifier:
NCT00784316
First received: October 31, 2008
Last updated: November 23, 2011
Last verified: November 2011
October 31, 2008
November 23, 2011
August 2007
July 2009   (Final data collection date for primary outcome measure)
Incidence of atrial fibrillation [ Time Frame: 48 hours ]
Same as current
Complete list of historical versions of study NCT00784316 on ClinicalTrials.gov Archive Site
Not Provided
Not Provided
Not Provided
Not Provided
 
Intravenous Metoprolol Versus Intravenous Amiodarone in the Prevention of Atrial Fibrillation After Cardiac Surgery
Intravenous Metoprolol Versus Intravenous Amiodarone in the Prevention of Atrial Fibrillation After Cardiac Surgery
The aim of the study is to test the efficiency of intravenous administration of metoprolol versus intravenous administration of amiodarone in the prevention of atrial fibrillation after cardiac surgery.
Not Provided
Interventional
Phase 4
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Prevention
  • Atrial Fibrillation
  • Cardiac Surgery
Drug: metoprolol, amiodarone
to compare the effectiviness of intravenous administration of metoprolol and amiodarone in the prevention of atrial fibrillation after cardiac surgery
  • Active Comparator: metoprolol
    Intervention: Drug: metoprolol, amiodarone
  • Active Comparator: amiodarone
    Intervention: Drug: metoprolol, amiodarone
Halonen J, Loponen P, Järvinen O, Karjalainen J, Parviainen I, Halonen P, Magga J, Turpeinen A, Hippeläinen M, Hartikainen J, Hakala T. Metoprolol versus amiodarone in the prevention of atrial fibrillation after cardiac surgery: a randomized trial. Ann Intern Med. 2010 Dec 7;153(11):703-9. doi: 10.7326/0003-4819-153-11-201012070-00003.

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
316
July 2009
July 2009   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • elective CABG and aortic valve patients in cardiac surgery,
  • previous use of betablocker therapy

Exclusion Criteria:

  • previous atrial fibrillation or flutter,
  • thyroid disease,
  • uncontrolled heart failure,
  • II or III degree atrioventricular block
Sexes Eligible for Study: All
Child, Adult, Senior
No
Contact information is only displayed when the study is recruiting subjects
Finland
 
 
NCT00784316
KUH5204005
No
Not Provided
Not Provided
Jari Halonen, Kuopio University Hospital
Kuopio University Hospital
  • Tampere University Hospital
  • Vaasa Central Hospital, Vaasa, Finland
Not Provided
Kuopio University Hospital
November 2011

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP