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Preoperative Assessment of Aortic Valve Stenosis and Coronary Artery Disease

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified April 2013 by Prof. Paul Erne, Luzerner Kantonsspital.
Recruitment status was:  Recruiting
Sponsor:
ClinicalTrials.gov Identifier:
NCT00767013
First Posted: October 6, 2008
Last Update Posted: April 17, 2013
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
Prof. Paul Erne, Luzerner Kantonsspital
October 3, 2008
October 6, 2008
April 17, 2013
May 2007
December 2013   (Final data collection date for primary outcome measure)
Quality of cardiac imaging in computed tomography [ Time Frame: After comparison of imaging measurements ]
Same as current
Complete list of historical versions of study NCT00767013 on ClinicalTrials.gov Archive Site
Not Provided
Not Provided
Not Provided
Not Provided
 
Preoperative Assessment of Aortic Valve Stenosis and Coronary Artery Disease
Preoperative Assessment of Aortic Valve Stenosis and Coronary Artery Disease: Dual-source Computed Tomography Compared With Invasive Coronary Angiography and Transthoracic Echocardiography
We sought to determine whether the dual-source computed tomography assessment of aortic valve stenosis and coronary artery disease is equivalent to or even better than conventional invasive coronary angiography and transthoracic echocardiography.

Until now invasive coronary angiography has established itself for the assessment of symptomatic aortic valve stenosis. Literature shows a good correlation between MSCT, MRI, TTE and TEE for evaluating the severity of the aortic valve stenosis.

The dual-source computed tomography (DSCT) is capable of assessing coronary arteries with a high sensitivity and specificity in term of relevant stenosis (>50%), due to its excellent spatial and temporal resolution. This study includes the assessment of patients with symptomatic valve stenosis. The severity of the aortic valve stenosis is being assessed by DSCT and TTE. Significant coronary artery stenosis and its localisation are assessed by DSCT and invasive coronary angiography. We examine the correlation between DSCT on one side and either TTE or invasive coronary angiography on the other.

Interventional
Not Provided
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Diagnostic
  • Aortic Valve Stenosis
  • Coronary Disease
Other: DSCT, TTE
One assessment each
Experimental: AVS, CAD
DSCT
Intervention: Other: DSCT, TTE
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Unknown status
65
Not Provided
December 2013   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • Patients with aortic valve disease who were scheduled to undergo cardiac surgery

Exclusion Criteria:

  • Hemodynamic instability
  • Renal insufficiency (serum creatinine level > 133umol/L)
  • Known allergy to iodinated contrast agents
  • Non-treated hyperthyreosis
Sexes Eligible for Study: All
40 Years and older   (Adult, Senior)
No
Contact information is only displayed when the study is recruiting subjects
Switzerland
 
 
NCT00767013
Cardiac imaging DSCT
Yes
Not Provided
Not Provided
Prof. Paul Erne, Luzerner Kantonsspital
Luzerner Kantonsspital
Not Provided
Principal Investigator: Paul Erne, MD Luzerner Kantonsspital
Luzerner Kantonsspital
April 2013

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP