Oxidative Stress in Critical Ill Patients in Surgical Intensive Care Unit

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00745888
Recruitment Status : Unknown
Verified August 2009 by National Taiwan University Hospital.
Recruitment status was:  Recruiting
First Posted : September 3, 2008
Last Update Posted : September 9, 2009
Information provided by:
National Taiwan University Hospital

September 2, 2008
September 3, 2008
September 9, 2009
May 2007
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28-day Survival [ Time Frame: 28 days ]
Same as current
Complete list of historical versions of study NCT00745888 on Archive Site
Days stay in ICU Days on ventilator SOFA score Complications [ Time Frame: 28 days ]
Same as current
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Oxidative Stress in Critical Ill Patients in Surgical Intensive Care Unit
Oxidative Stress in Critical Ill Patients in Surgical Intensive Care Unit

In clinical practice, the oxidative stress is related to circulatory shock, sepsis, acute lung injury, and acute respiratory distress syndrome. There are some questions on the oxidative stress of the critical illness. First, the investigators want to search out the effects of the past history, smoking, alcohol drinking, use of antioxidants, different diseases, and different duration of SIRS on the degree of oxidative stress. Second, besides total count of ROS, the investigators used new techniques to determine superoxide(O2●-), hydrogen peroxide (H2O2), and hypochlorous acid(HOCl). Furthermore, we want to investigate the correlation of the degree of different reactive oxygen species and the severity of SIRS or shock. Third, we try to investigate the correlation between the change of oxidative stress and the prognosis of the patients.

The investigators wish this study will help them to investigate the effect of oxidative stress on critical ill patients, to modulate the oxidative stress, to decrease the occurrence of SIRS, shock, and multiorgan failure, and to improve the long term outcome of patients.

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Time Perspective: Prospective
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Retention:   Samples Without DNA
blood sample
Probability Sample
Patients admitted to surgical ICU
  • Sepsis
  • Shock
Other: Chemiluminescence Analyzer
measure reactive oxygen species
age > 18 y/o Patients admitted to surgical ICU
Intervention: Other: Chemiluminescence Analyzer
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*   Includes publications given by the data provider as well as publications identified by Identifier (NCT Number) in Medline.
Unknown status
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Inclusion Criteria:

  • Age > 18 y/o
  • Admitted to surgical ICU

Exclusion Criteria:

  • Patients with brain death
Sexes Eligible for Study: All
18 Years and older   (Adult, Senior)
Contact information is only displayed when the study is recruiting subjects
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Yu-Chang Yeh, National Taiwan University Hospital
National Taiwan University Hospital
Not Provided
Principal Investigator: Yu-Chang Yeh National Taiwan University Hospital
National Taiwan University Hospital
August 2009