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hCAP18 Levels and Vitamin D Deficiency in Healthy Subjects

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00742235
First Posted: August 27, 2008
Last Update Posted: April 14, 2016
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
Ishir Bhan, MD, MPH, Massachusetts General Hospital
August 25, 2008
August 27, 2008
June 5, 2013
November 11, 2013
April 14, 2016
July 2007
January 2012   (Final data collection date for primary outcome measure)
  • hCAP18 Levels [ Time Frame: Baseline ]
  • Baseline 25-OH Vitamin D Level [ Time Frame: Baseline ]
hCAP18 Levels [ Time Frame: 2 weeks ]
Complete list of historical versions of study NCT00742235 on ClinicalTrials.gov Archive Site
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hCAP18 Levels and Vitamin D Deficiency in Healthy Subjects
hCAP18 Levels and Vitamin D Deficiency in Healthy Subjects
Vitamin D deficiency (low levels of vitamin D in the blood) is a common problem. A recently discovered protein, called hCAP18, likely plays an important role in the immune system and may depend on adequate levels of vitamin D. It is not known what levels of vitamin D are needed to allow the body to make this protein. Nor is it known if giving vitamin D to people who are found to be deficient will help boost levels of hCAP18. This study aims to clarify the relationship between vitamin D levels and hCAP18.
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Interventional
Not Provided
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
  • Healthy Subjects
  • Vitamin D Deficiency
Drug: ergocalciferol
Ergocalciferol 50,000 IU given every other day for 5 total doses
Other Name: Vitamin D
  • Experimental: 1
    Vitamin D insufficient (treated with ergocalciferol 50,000 IU every other day x 5 doses)
    Intervention: Drug: ergocalciferol
  • No Intervention: Vitamin D sufficient
    Subjects who did not receive ergocalciferol and had a 25-OH vitamin D level >32 ng/ml
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
99
January 2012
January 2012   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • Age 18-80

Exclusion Criteria:

  • Known active infectious disease or chronic inflammatory disorder
  • Hypercalcemia
  • Chronic kidney disease
  • Pregnancy
Sexes Eligible for Study: All
18 Years to 80 Years   (Adult, Senior)
Yes
Contact information is only displayed when the study is recruiting subjects
United States
 
 
NCT00742235
2008-P-0003000/1
No
Not Provided
Not Provided
Ishir Bhan, MD, MPH, Massachusetts General Hospital
Massachusetts General Hospital
Not Provided
Principal Investigator: Ishir Bhan, MD MPH Massachusetts General Hospital
Massachusetts General Hospital
March 2016

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP