Memory and Picture Viewing Study (MPVS)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00736203
Recruitment Status : Completed
First Posted : August 15, 2008
Last Update Posted : February 7, 2013
National Institutes of Health (NIH)
Information provided by (Responsible Party):
Duke University

August 13, 2008
August 15, 2008
February 7, 2013
July 2008
November 2011   (Final data collection date for primary outcome measure)
brain reactivity [ Time Frame: 3 weeks ]
Same as current
Complete list of historical versions of study NCT00736203 on Archive Site
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Memory and Picture Viewing Study
Memory and Picture Viewing Study
The purpose of this study is to obtain a database of brain function from a sample of non-smokers while they do tasks in an MRI (magnetic resonance imaging) machine. Our hypothesis is that among nonsmokers, reactivity to smoking cues will be highly similar to control cues but may vary as a function of attitudes toward smoking and/or family history of smoking. We also hypothesize that brain activity during the n-back task will be more similar to data collected during this task when smokers are not abstinent.

Thirty six non-smokers will undergo functional magnetic resonance imaging (fMRI) scanning. During scanning participants will complete the n-back task-a measure of working memory-and the cue-reactivity task-a measure of responses to smoking cues. Before scanning, participants will complete a training session where they will be familiarized with the tasks.

All participants will have to pass a screening visit in order to be included in the study.

Observational Model: Cohort
Time Perspective: Prospective
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Retention:   Samples With DNA
saliva, blood
Probability Sample
generally healthy, right-handed non-smokers, between the ages of 18-55, having smoked less than 50 cigarettes in their lifetime
  • Healthy
  • Brain Reactivity of Non-smokers Undergoing fMRI Scanning
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*   Includes publications given by the data provider as well as publications identified by Identifier (NCT Number) in Medline.
November 2011
November 2011   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • generally healthy
  • right-handed non-smokers
  • between the ages of 18-55
  • an expired CO concentration of 5 ppm or less; or a negative urine cotinine test of 100 ng/mL or less (to confirm a non-smoker)
  • having smoked < 50 cigarettes in their lifetime

Exclusion Criteria:

  • inability to attend all sessions
  • significant health problems (hypertension, emphysema, seizure disorder, history of significant heart problems)
  • use of psychoactive medications
  • use of any tobacco or nicotine containing products
  • current alcohol or drug abuse
  • use of illegal drugs as measure by a urine drug screen
  • presence of conditions that would make MRI unsafe (pacemaker, metallic implants
Sexes Eligible for Study: All
18 Years to 55 Years   (Adult)
Contact information is only displayed when the study is recruiting subjects
United States
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Duke University
Duke University
National Institutes of Health (NIH)
Principal Investigator: Joseph McClernon, PhD Duke University
Duke University
January 2013