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Cortico-cortical Connectivity During Midazolam Sedation in Humans; a TMS/EEG Study

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00734006
First Posted: August 13, 2008
Last Update Posted: May 7, 2015
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
University of Wisconsin, Madison
August 11, 2008
August 13, 2008
May 7, 2015
July 2008
March 2010   (Final data collection date for primary outcome measure)
Defining the neurophysiological conditions that are necessary for conscious experience. [ Time Frame: Immediate ]
Same as current
Complete list of historical versions of study NCT00734006 on ClinicalTrials.gov Archive Site
Understanding the neurophysiological correlates of conditions associated with restricted conscious experience such as sedation and anesthesia. [ Time Frame: Immediate ]
Same as current
Not Provided
Not Provided
 
Cortico-cortical Connectivity During Midazolam Sedation in Humans; a TMS/EEG Study
Cortico-cortical Connectivity During Midazolam Sedation in Humans; a TMS/EEG Study
The aim of the proposed research is to measure the effect of drug-induced sedation on the functional connectivity between brain regions as indicated by EEG signal transmission within the human brain. The results of this study will help to identify the neurophysiological correlates of changes in conscious experience that occur during drug-induced sedation.
In the proposed experiments cortical areas will be stimulated using low frequency, low-amplitude transcranial magnetic stimulation (TMS) in healthy human subjects during wakefulness and during drug-induced responsive sedation and unresponsive sedation. Simultaneously, high-density electroencephalography (Hd-EEG) will be recorded to evaluate the temporal and spatial characteristics of evoked responses and induced rhythms over the cortex.
Observational
Observational Model: Case Control
Time Perspective: Prospective
Not Provided
Not Provided
Probability Sample
Healthy right-handed men aged 18-35 who do not smoke or have any metallic implants may be eligible for this study.
Healthy
Not Provided
Not Provided
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
20
March 2010
March 2010   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • Healthy right-handed men
  • Aged 18-35
  • Non-smokers
  • No metallic implants

Exclusion Criteria:

  • Younger than 18 or over the age of 35.
Sexes Eligible for Study: Male
18 Years to 35 Years   (Adult)
Yes
Contact information is only displayed when the study is recruiting subjects
United States
 
 
NCT00734006
2008-0018
Yes
Not Provided
Not Provided
University of Wisconsin, Madison
University of Wisconsin, Madison
Not Provided
Principal Investigator: Robert Pearce, MD, PhD University of Wisconsin, Madison
University of Wisconsin, Madison
May 2015