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Association Study of Gene Polymorphisms With Cardiac Performance

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ClinicalTrials.gov Identifier: NCT00730899
Recruitment Status : Unknown
Verified August 2008 by University Hospital, Essen.
Recruitment status was:  Recruiting
First Posted : August 8, 2008
Last Update Posted : August 8, 2008
Sponsor:
Information provided by:
University Hospital, Essen

August 4, 2008
August 8, 2008
August 8, 2008
May 2008
January 2011   (Final data collection date for primary outcome measure)
genotype dependent change of hemodynamic variables [ Time Frame: one day ]
Same as current
No Changes Posted
all cause mortality [ Time Frame: 60 days ]
Same as current
Not Provided
Not Provided
 
Association Study of Gene Polymorphisms With Cardiac Performance
Observational Association Study of G Protein Polymorphisms With Cardiac Performance in Coronary Artery Disease Patients Undergoing Coronary Artery Bypass Grafting
The purpose of this study is to determine whether polymorphisms in G protein subunits, namely Galphas and Galphaq, are associated with altered cardiac performance in heart failure patients.
G Protein pathways plays a pivotal role in mediating positive inotropy and cardiac hypertrophy by transducing signals of neurohormones in cardiomyocytes. Single nucleotide polymorphisms (SNPs) in the G protein subunits Galphas and Galphaq have been shown to result in altered protein expression. We now want to examine whether G Protein polymorphisms alter NYHA functional class, and hemodynamic variables in patients with coronary artery disease scheduled for coronary artery bypass grafting .
Observational
Observational Model: Cohort
Time Perspective: Prospective
Not Provided
Retention:   Samples With DNA
Description:
whole blood
Non-Probability Sample
Patients with coronary artery disease scheduled for coronary artery bypass grafting in the university hospital
  • Genetic Polymorphism
  • Coronary Artery Disease
  • Hemodynamics
Not Provided
Not Provided
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Unknown status
500
Same as current
June 2011
January 2011   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • clinical diagnosis of coronary artery disease
  • patients scheduled for coronary artery bypass grafting

Exclusion Criteria:

  • emergency operation
  • combined vitium
Sexes Eligible for Study: All
18 Years to 80 Years   (Adult, Senior)
No
Contact information is only displayed when the study is recruiting subjects
Germany
 
 
NCT00730899
HOT-001
No
Not Provided
Not Provided
Ulrich Frey, University Hospital Essen
University Hospital, Essen
Not Provided
Study Director: Jürgen Peters, MD University Hospital, Essen
University Hospital, Essen
August 2008