The Absorption of Vitamin B12 Among Healthy Pregnant Women

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00730093
Recruitment Status : Completed
First Posted : August 8, 2008
Last Update Posted : August 6, 2009
Information provided by:
University of Aarhus

July 11, 2008
August 8, 2008
August 6, 2009
August 2008
July 2009   (Final data collection date for primary outcome measure)
Change in vitamin B12 absorption during pregnancy, measured with CobaSorb. [ Time Frame: 9 month ]
Same as current
Complete list of historical versions of study NCT00730093 on Archive Site
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Difference in vitamin B12 absorption, measured with CobaSorb, between pregnant healthy women and non-pregnant healthy women [ Time Frame: 6 month ]
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The Absorption of Vitamin B12 Among Healthy Pregnant Women
The Absorption of Vitamin B12 Among Healthy Pregnant Women

During pregnancy the woman uses more vitamin B12, but we do not know, whether it is through increased absorption or it eats into the womans vitamin B12 deposit . Sufficient B-vitamin is crucial for the normal development af foetus during pregnancy.

In Denmark the National Board of Health recommend an intake of Folic Acid, from the day the woman wishes to be pregnant and to the 12. week of gestation, but there is no recommendation for vitamin B12. We will measure the vitamin B12 absorption with a new non-radioactive test, CobaSorb.

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Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Supportive Care
Dietary Supplement: B12 vitamin (Cyanocobalamin)
Arm A: B12 vitamin (Cyanocobalamin)
Intervention: Dietary Supplement: B12 vitamin (Cyanocobalamin)
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*   Includes publications given by the data provider as well as publications identified by Identifier (NCT Number) in Medline.
August 2009
July 2009   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • the 13 week of gestation +/- 1 week (only fore pregnant women)
  • Between 20- 40 years
  • Northern European
  • abel to read and understand danish

Exclusion Criteria:

  • treatment with vitamin B12 within the last 5 years
  • daily intake of vitamins that contain more than 1µg vitamin B12
  • infectious disease
  • systemic disease
  • daily use of medicine that interferes with vitamin B12
Sexes Eligible for Study: Female
20 Years to 40 Years   (Adult)
Contact information is only displayed when the study is recruiting subjects
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Professor, md, Ebba Nexø, Klinisk Biokemisk Afd., Århus Universitetshospital, Århus Sygehus,
University of Aarhus
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Study Chair: Ebba Nexø, Professor Aarhus Universitetshospital, Aarhus Sygehus
University of Aarhus
August 2009

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP