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Fractalkine, a CX3C Chemokine, Act as a Mediator of Ocular Angiogenesis

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ClinicalTrials.gov Identifier: NCT00728598
Recruitment Status : Completed
First Posted : August 6, 2008
Last Update Posted : August 6, 2008
Information provided by:
National Taiwan University Hospital

August 1, 2008
August 6, 2008
August 6, 2008
January 1998
December 1998   (Final data collection date for primary outcome measure)
Vitreous levels and serum levels of Fractalkine, VEGF, other growth factor. [ Time Frame: vitreous sample collected on vitrectomy ]
Same as current
No Changes Posted
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Fractalkine, a CX3C Chemokine, Act as a Mediator of Ocular Angiogenesis
Vitreous Levels of Patients With Proliferative Diabetic Retinopathy.
Fractalkine (FKN) is a chemoattractant and adhesion molecule for leukocytes. Angiogenic effect of FKN also has been reported. We investigate FKN-mediated angiogenesis in ocular angiogenic disorders.
Fractalkine (FKN), the sole member of the CX3C chemokine family, is named for its fractal geometry. The CX3C motif, with three amino acids between the two terminal cysteines, makes fractalkine distinct from other chemokines.The structure of fractalkine, a membrane-bound glycoprotein with the chemokines domain atop an extended mucin-like stalk, also is unique.Membrane-bound FKN can be markedly induced on primary endothelial cells by inflammatory cytokines; this form promotes the robust adhesion of monocytes and T lymphocytes. Soluble FKN can be released by proteolysis at an efficient chemotactic activity level for monocytes and T cells. Thus, FKN is a versatile molecule regulating both cell-cell interactions in its membrane-bound form and directed-cell migration in its soluble form. The receptor of FKN, CXC3R1, is a G protein-couple protein, which expresses T lymphocytes, monocytes, natural killer (NK) cells, microglia, and neurons.Sulfation of tyrosine enhances the function of CX3CR1 in cell capture and firm adhesion. Fractalkine is expressed constitutively in the kidney, heart, lung, and brain. Fractalkine has demonstrated an important role in CNS inflammation, cardiac allograft rejection, arteriogenesis, renal disease, psoriasis, and during pregnancy. Silverman et al demonstrated the presence of FKN in normal cultured microvascular endothelial and stromal cells of iris and retina in vitro. Upon inflammatory cytokine stimulation, EC also express FKN and its receptors with FKN secretion in an autocrine manner. In addition to EC chemotaxis and tube formation, FKN is an angiogenic mediator in rheumatoid arthritis. Therefore, we hypothesize that FKN not only participates in ocular inflammatory reactions, but also plays an important role in ocular angiogenesis.
Observational Model: Case Control
Time Perspective: Prospective
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Retention:   Samples Without DNA
Vitreous sample and blood sample
Non-Probability Sample
Patients with proliferative diabetic retinopathy, who will receive vitrectomy.
  • Proliferative Diabetic Retinopathy
  • Angiogenesis
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  • 1
    Proliferative diabetic retinopathy, active.
  • 2
    Proliferative diabetic retinopathy, quiescent.
  • 3
    Control group. Patients with macular hole or idiopathic epiretinal membrane receiving vitrectomy for their disease.

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
December 1998
December 1998   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • clinical diagnosis of proliferative diabetic retinopathy.
  • who will receive vitrectomy for treatment of disease.

Exclusion Criteria:

  • previous ocular surgical history.
  • history of uveitis
  • history of ocular trauma.
Sexes Eligible for Study: All
Child, Adult, Senior
Contact information is only displayed when the study is recruiting subjects
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National Taiwan University Hospital
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Principal Investigator: Chang-Hao Yang, MD, PhD Ophthalmology, National Taiwan University Hospital
National Taiwan University Hospital
August 2008