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Endoscopic Saphenous Vein Harvest for Coronary Artery Bypass Grafting

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00712192
First Posted: July 9, 2008
Last Update Posted: July 9, 2008
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
Far Eastern Memorial Hospital
July 7, 2008
July 9, 2008
July 9, 2008
January 2007
December 2007   (Final data collection date for primary outcome measure)
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No Changes Posted
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Endoscopic Saphenous Vein Harvest for Coronary Artery Bypass Grafting
The Impact on Endothelial Function and Integrity by Endoscopic Saphenous Vein Harvest for Coronary Artery Bypass Grafting
Although the long saphenous vein remains the most commonly used conduit in coronary revascularization, traditional open vein harvest may lead to significantly impaired wound healing and post-operative pain. To this end, endoscopic saphenous vein harvesting techniques have been shown to reduce post-operative morbidity. Studies have shown that endothelial integrity and luminal nitric oxide synthase (NOS) are better preserved with novel "no-touch" techniques; however, the effect and the associated mechanism of endoscopic vein harvest on endothelial integrity and function remain unknown. Therefore, in the present proposal, we will collect the saphenous vein segements immediately after harvesting, reperfusion, and grafting, and then use enzyme-linked immunosorbant assay (ELISA), immunohistochemical staining (IHC), and real-time polymerase chain reaction (RT-PCR) to detect the expression and distribution of endothelial NOS (eNOS), endothelin-1 (ET-1), vascular cell adhesion molecule-1 (VCAM-1), intracellular adhesion molecule-1 (ICAM-1), and platelet endothelial cell adhesion molecule-1(PECAM-1) at protein and RNA levels in the endothelium of saphenous veins. The major aim of this study is to elucidate the effect and mechanism of endoscopic saphenous vein harvesting on endothelial properties as compare to conventional open vein harvest technique.
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Interventional
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Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Basic Science
Coronary Artery Disease
Procedure: coronary artery bypass grafting
patient with coroary artery diseases underwent coronary artery bypass grafting surgery
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
34
December 2007
December 2007   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • patient with coronary artery disease underwent coronary artery bypass grafting in our hospital

Exclusion Criteria:

Sexes Eligible for Study: All
Child, Adult, Senior
No
Contact information is only displayed when the study is recruiting subjects
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NCT00712192
95016
FEMH - 95 - C -002
Yes
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Shih-Hong Huang, Far Eastern Memorial Hospital
Far Eastern Memorial Hospital
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Far Eastern Memorial Hospital
July 2008

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP