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Color Doppler Imaging of Orbital Venous Flow in Grave's Orbitopathy

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ClinicalTrials.gov Identifier: NCT00697528
Recruitment Status : Completed
First Posted : June 16, 2008
Last Update Posted : December 19, 2013
Information provided by:

June 11, 2008
June 16, 2008
December 19, 2013
January 2007
December 2008   (Final data collection date for primary outcome measure)
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Complete list of historical versions of study NCT00697528 on ClinicalTrials.gov Archive Site
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Color Doppler Imaging of Orbital Venous Flow in Grave's Orbitopathy
Color Doppler Imaging of Orbital Venous Flow in Grave's Orbitopathy
Orbital Venous flow study in patients with Grave's Orbitopathy in different manifestation forms and stages, made with Color Doppler Imaging

Prospective study with Grave's patients in active and fibrotic disease, myogenic and lipogenic forms, with muscle restriction and without muscle restriction and with or without optic compressive neuropathy. Blood flow was studied with Color Doppler Imaging (CDI) in the following orbital vessels:

  • Superior Ophthalmic Vein (main target of the study protocol)
  • Retinal Central Vein
  • Retinal Central Artery
  • Ophthalmic Artery
Observational Model: Case Control
Time Perspective: Prospective
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Non-Probability Sample
Patients with Grave's disease within the orbital service of HCFMUSP at the Ophthalmology Department
  • Graves' Disease
  • Graves' Ophthalmopathy
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  • Group control with healthy subjects
    Healthy subjects without thyroid disease, ocular disease and previous surgery in the orbit or eye used in the study.
  • Graves' Ophthalmopathy - fibrotic phase
    Patients that are clinically inactive (CAS equal or lower than 2). This group will be subdivided in the miogenic and lipogenic groups.
  • Graves' Ophthalmopathy - active phase
    Patients that are clinically active, presenting a CAS of 4 or more points, with or without disthyroid optic neuropathy.
Monteiro ML, Moritz RB, Angotti Neto H, Benabou JE. Color Doppler imaging of the superior ophthalmic vein in patients with Graves' orbitopathy before and after treatment of congestive disease. Clinics (Sao Paulo). 2011;66(8):1329-34.

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
December 2008
December 2008   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • Clinical diagnosis of Grave's Orbitopathy with well defined disease.

Exclusion Criteria:

  • Uncertain cases, with an undefined status of Grave's Ophthalmopathy.
Sexes Eligible for Study: All
18 Years to 70 Years   (Adult, Senior)
Contact information is only displayed when the study is recruiting subjects
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Hélio Angotti Neto, HCFMUSP - University of São Paulo
University of Sao Paulo
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Study Director: Mário LR Monteiro, Professor Instituto do Coracao
Study Chair: Joseph E Benabou Instituto do Coracao
University of Sao Paulo
June 2008