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The Effect of Clopidogrel on Coated-Platelets in Patients Undergoing Cardiac Catheterization

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ClinicalTrials.gov Identifier: NCT00644657
Recruitment Status : Completed
First Posted : March 27, 2008
Results First Posted : October 7, 2011
Last Update Posted : October 7, 2011
Sponsor:
Information provided by (Responsible Party):
University of Oklahoma

March 24, 2008
March 27, 2008
January 6, 2011
October 7, 2011
October 7, 2011
March 2007
September 2008   (Final data collection date for primary outcome measure)
The Percentage of Coated Platelets After the Administration of Clopidogrel in Patients Undergoing Cardiac Catheterization and/or Angioplasty [ Time Frame: 24 hours after the administration of clopidotrel ]
The percentage of platelets that are collagen coated after the administration of clopidogrel.
Change in the percentage of coated platelets [ Time Frame: Within 24 hours ]
Complete list of historical versions of study NCT00644657 on ClinicalTrials.gov Archive Site
The Percentage of Coated Platelets After Coronary Angiography and/or PCI [ Time Frame: 6 hrs after procedure ]
The percentage of coated platelets 24 hours after coronary angiography and/or PCI
Not Provided
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The Effect of Clopidogrel on Coated-Platelets in Patients Undergoing Cardiac Catheterization
The Effect of Clopidogrel on Coated-Platelets in Patients Undergoing Cardiac Catheterization
This study will explore the effect of clopidogrel on coated-platelets in patients who are given a loading dose before diagnostic catheterization or percutaneous coronary intervention. We hypothesis that clopidogrel will reduce the percentage of platelets that are coated and therefore more hypercoagulable.
Platelet activity will be determined by light transmission aggregometry at baseline, after a 300 mg dose of clopidogrel and after the catheterization and/or angioplasty procedure. The change in the percentage of platelets that are coated platelets will be determined.
Interventional
Not Applicable
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Basic Science
  • Coronary Artery Disease
  • Chest Pain
Drug: Clopidogrel
All subjects will receive a 300 mg loading dose
Other Name: Plavix
Not Provided
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
27
32
September 2008
September 2008   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • Patients given clopidogrel loading dose before scheduled catheterization or percutaneous intervention

Exclusion Criteria:

  • Acute coronary syndrome
  • Unable to tolerate clopidogrel
Sexes Eligible for Study: All
18 Years to 65 Years   (Adult, Older Adult)
No
Contact information is only displayed when the study is recruiting subjects
United States
 
 
NCT00644657
13291
No
Not Provided
Not Provided
University of Oklahoma
University of Oklahoma
Not Provided
Principal Investigator: Eliot Schechter, MD University of Oklahoma
University of Oklahoma
September 2011

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP