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The Correlation Between Oxidative Stress and Indinated Contrast-Media Nephrotoxicity

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00632892
First Posted: March 11, 2008
Last Update Posted: March 11, 2008
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
Far Eastern Memorial Hospital
March 3, 2008
March 11, 2008
March 11, 2008
December 2007
January 2008   (Final data collection date for primary outcome measure)
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No Changes Posted
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The Correlation Between Oxidative Stress and Indinated Contrast-Media Nephrotoxicity
The Correlation Between Oxidative Stress and Indinated Contrast-Media Nephrotoxicity

Clinically, iodinated contrast-medium (CM) is widely used in angiography and computerized tomography. CM-induced nephropathy (CMIN) is one major complication after application of CM. Therefore, how to prevent CMIN is always one of the hot topics concerned by nephrologists, cardiologists, and radiologists.

The present study is aimed to determine the norepinephrine concentration, oxidative markers, and tubular damage markers in the urine samples of patients undergoing intravenous pyelography (IVP).

The working hypothesis is high-osmolarity contrast media (HOCM) causes more oxidative stress and greater tubular damage than iso-osmolarity contrast media (IOCM).

Not Provided
Observational
Observational Model: Case-Only
Time Perspective: Prospective
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Retention:   Samples Without DNA
Description:
The urine samples are collected just before and 30 minutes after IVP.The samples are immediately frozen at -80'C until analyzed.
Non-Probability Sample
  1. Adult patients (> 18 years old)
  2. Undergoing IVP with an appropriate medical indication
  3. Signing informed consent
Kidney Diseases
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
80
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January 2008   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  1. Adult patients (> 18 years old)
  2. Undergoing IVP with an appropriate medical indication
  3. Signing informed consent

Exclusion Criteria:

1. Without signing informed consent

Sexes Eligible for Study: All
18 Years and older   (Adult, Senior)
No
Contact information is only displayed when the study is recruiting subjects
Taiwan
 
 
NCT00632892
96013
Yes
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Far Eastern Memorial Hospital
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Far Eastern Memorial Hospital
February 2008