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Breath Analysis by Ion Mobility Spectrometry

This study is currently recruiting participants. (see Contacts and Locations)
Verified September 2016 by Lung Clinic Hemer
Information provided by (Responsible Party):
Michael Westhoff MD, Lung Clinic Hemer Identifier:
First received: February 29, 2008
Last updated: September 6, 2016
Last verified: September 2016

February 29, 2008
September 6, 2016
July 2006
June 2020   (Final data collection date for primary outcome measure)
Identification of diseases specific VOCs [ Time Frame: years ]
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Complete list of historical versions of study NCT00632307 on Archive Site
Change of disease specific VOCs under therapy [ Time Frame: years ]
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Breath Analysis by Ion Mobility Spectrometry
Detection of Clusters of Volatile Organic Compounds (VOC)in Patients With Different Lung Disorders by Ion Mobility Spectrometry. Different Clusters of VOC in the Diagnosis of Different Lung Disorders Using Ion Mobility Spectrometry

Recognition of disease specific clusters of volatile organic compounds in patients with different lung diseases, using breath analysis with ion mobility spectrometry. Lung diseases of interest are:

  • COPD
  • tumors
  • airway infection
  • interstitial lung disease
  • sleep apnea Hypothesis: Breath analysis with ion mobility spectrometry can differentiate pulmonary disorders.
Recruitment of patients with different lung diseases goes on. First sub-group analysis of patients with COPD,lung cancer and sarcoidosis is done in order to create a training set of VOC-clusters for further validation in a bigger population of patients.
Time Perspective: Prospective
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Retention:   Samples Without DNA
breath, pleural fluid (only in patients with therapeutic pleurocentesis)
Non-Probability Sample
patients of the lung clinic hemer with pulmonary diseases.
Lung Diseases
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  • 1
  • 2
    lung cancer
  • 3
    airway infection
  • 4
    interstitial lung disease
  • 5
    sleep apnea
  • 6
    pulmonary disorders with pleural infusions
  • 7
  • 8
    healthy persons

*   Includes publications given by the data provider as well as publications identified by Identifier (NCT Number) in Medline.
June 2020
June 2020   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • Any patient
  • Ages 18-90 years old

Exclusion criteria:

- Patient who are not able to perform an exhalation manoever.

Sexes Eligible for Study: All
18 Years to 90 Years   (Adult, Senior)
Contact: Michael Westhoff, MD 004923729082203
Contact: Patric Litterst, MD 004923729082545
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Michael Westhoff MD, Lung Clinic Hemer
Lung Clinic Hemer
Not Provided
Principal Investigator: Michael Westhoff, MD Lung Clinic Hemer, 58675 Hemer, Germany
Lung Clinic Hemer
September 2016

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP