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Vitamin A, Its Receptors and Asthma

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
ClinicalTrials.gov Identifier: NCT00628329
Recruitment Status : Withdrawn
First Posted : March 5, 2008
Last Update Posted : May 7, 2012
Information provided by (Responsible Party):

February 26, 2008
March 5, 2008
May 7, 2012
May 2008
December 2012   (Final data collection date for primary outcome measure)
Retinol levels in blood, flow cytometric study of the RXRRAR receptors before and after addition of ATRA, 9-cis-RA and steroid [ Time Frame: 2-4 weeks after blood sample drawn ]
Same as current
Complete list of historical versions of study NCT00628329 on ClinicalTrials.gov Archive Site
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Vitamin A, Its Receptors and Asthma
Vitamin A, Its Receptors and Asthma: Vitamin A Levels in Serum and Expression and Responsiveness of Vitamin A Receptors in Circulating Mononuclear Cells of Asthmatics
We wish to understand the association of Vitamin A serum levels and Vitamin A receptor number and responsiveness in asthmatics. We believe that Vitamin A receptors may be less prevalent in asthmatics and their responsiveness decreased.
We wish to define the association of asthma, vitamin A serum levels and vitamin A receptor number and responsiveness on circulating mononuclear cells. Asthma is a complex, heterogenous and often debilitating and potentially deadly disease. The causes for asthma are many, with susceptibility and resistance to treatment is poorly understood. Ultimately, looking at this disease from another angle such as the role of Vitamin A and/or receptors can help us learn more about the pathophysiology and treatment of asthma.
Observational Model: Cohort
Time Perspective: Cross-Sectional
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Retention:   Samples With DNA
Serum without DNA, cells with DNA
Non-Probability Sample
Male or female Age 18-64
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  • 1
  • 2
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
December 2012
December 2012   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • Patients with previously diagnosed asthma on inhaled corticosteroids, systemic steroids and/or long acting beta agonist (for a period of 6 mo to 5 years)
  • Age 18-64
  • Male or female

Exclusion Criteria:

  • Children under age 18
  • Adults 65 or older
  • Patients with COPD
Sexes Eligible for Study: All
18 Years to 64 Years   (Adult)
Contact information is only displayed when the study is recruiting subjects
United States
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Selina Gierer, D.O., University of Kansas
University of Kansas
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Principal Investigator: Daniel Stechschulte, MD University of Kansas Medical Center
University of Kansas Medical Center
May 2012