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How Does Your Genetic Make-up (Profile) Influence Your Glaucoma?

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00626847
First Posted: February 29, 2008
Last Update Posted: November 21, 2016
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborators:
Jefferson Medical College of Thomas Jefferson University
Thomas Jefferson University
Information provided by (Responsible Party):
George L. Spaeth MD, Wills Eye
February 20, 2008
February 29, 2008
November 21, 2016
March 2008
August 2009   (Final data collection date for primary outcome measure)
The investigators will quantify the spectrum of changes in mitochondrial respiration, relative mitochondrial DNA content, and oxidative stress associated with different types of glaucoma. [ Time Frame: one blood draw ]
We will sequence the entire mitochondrial genome to determine mitochondrial DNA nucleotide changes associated with different types of glaucoma in ethnic Americans.
Complete list of historical versions of study NCT00626847 on ClinicalTrials.gov Archive Site
Not Provided
We will quantify the spectrum of changes in mitochondrial respiration, relative mitochondrial DNA content, and oxidative stress associated with different types of glaucoma.
Not Provided
Not Provided
 
How Does Your Genetic Make-up (Profile) Influence Your Glaucoma?
Nuclear Genetic and Mitochondrial Influences in Glaucoma
Glaucoma is a group of diseases in which visual loss occurs because of damage to the optic nerve. Research has shown that certain genes may cause glaucoma in some cases. So far, research has only been able to find the genes responsible for glaucoma in a small percentage of people who have glaucoma. The purpose of this project is to study the genes in patients with and without glaucoma to find additional genes that may be responsible for causing glaucoma.
Four tubes of blood will be taken from 100 people. Of those, half will have primary open angle glaucoma (POAG) and the other half will be controls (normals), half will be caucasians and the other half will be african americans, half male and half female. All groups will have a routine ophthalmic eye exam, color vision, snellen vision, and visual field done.
Observational
Observational Model: Cohort
Time Perspective: Prospective
Not Provided
Retention:   Samples With DNA
Description:
whole blood
Non-Probability Sample
glaucoma clinic
Primary Open Angle Glaucoma
Not Provided
  • 1
    Primary Open Angle Glaucoma (POAG)
  • 2
    Controls (Normals, patients without glaucoma)

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
97
August 2009
August 2009   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • 40 yrs
  • Caucasian or African American
  • Male or female with POAG, PACG, PXFG,
  • Normal

Exclusion Criteria:

  • Other ophthamic co-morbidities
  • Other ethnic groups
  • Unable to understand and give informed consent
Sexes Eligible for Study: All
40 Years and older   (Adult, Senior)
Yes
Contact information is only displayed when the study is recruiting subjects
United States
 
 
NCT00626847
IRB#07-826
No
Not Provided
Plan to Share IPD: Yes
Plan Description: Two manuscripts have been written and published.
George L. Spaeth MD, Wills Eye
Wills Eye
  • Jefferson Medical College of Thomas Jefferson University
  • Thomas Jefferson University
Principal Investigator: George L Spaeth, MD Wills Eye Institute
Wills Eye
November 2016