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Trial record 13 of 28 for:    "Turner Syndrome" | "Estrogens"

Long Term Follow-up of Bone Mineral Density in Hormone Treated Turner Syndrome

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ClinicalTrials.gov Identifier: NCT00625001
Recruitment Status : Unknown
Verified February 2008 by University of Aarhus.
Recruitment status was:  Active, not recruiting
First Posted : February 28, 2008
Last Update Posted : February 28, 2008
Sponsor:
Information provided by:
University of Aarhus

Tracking Information
First Submitted Date February 19, 2008
First Posted Date February 28, 2008
Last Update Posted Date February 28, 2008
Study Start Date November 1994
Actual Primary Completion Date October 1996   (Final data collection date for primary outcome measure)
Current Primary Outcome Measures
 (submitted: February 19, 2008)
Bone Mineral Density in columna lumbalis, collum femoris and distal ulnae Bone mineral density (BMD; grams/ square centimetre) were measured at lumbar spine, hip and the non-dominant forearm. [ Time Frame: Evey 5 years ]
Original Primary Outcome Measures Same as current
Change History No Changes Posted
Current Secondary Outcome Measures Not Provided
Original Secondary Outcome Measures Not Provided
Current Other Pre-specified Outcome Measures Not Provided
Original Other Pre-specified Outcome Measures Not Provided
 
Descriptive Information
Brief Title Long Term Follow-up of Bone Mineral Density in Hormone Treated Turner Syndrome
Official Title Long Term Follow-up of Bone Mineral Density in Hormone Treated Turner Syndrome
Brief Summary

Turner Syndrome (TS) is associated with osteopenia and osteoporosis. Reduced bone mineral density (BMD) and increased risk of fractures are present in many younger and middle-aged women with TS. The objective is therefore to describe longitudinal changes in BMD in TS.

The study is an observational follow-up study. Examinations at baseline, after 5 and 10 years.

Bone mineral density is measured by dual energy x-ray absorptiometry (DEXA) and bone turnover by bone markers.

Main Outcome Measures: Bone mineral density (BMD; grams/ square centimetre) were measured at lumbar spine, hip and the non-dominant forearm.

Detailed Description Not Provided
Study Type Observational
Study Design Observational Model: Cohort
Time Perspective: Prospective
Target Follow-Up Duration Not Provided
Biospecimen Retention:   Samples Without DNA
Description:
Blood samples
Sampling Method Non-Probability Sample
Study Population Women with Turner syndrome
Condition Turner Syndrome
Intervention Not Provided
Study Groups/Cohorts
  • 1
    Women with Turner syndrome
  • 2
    Healthy control women
Publications * Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruitment Information
Recruitment Status Unknown status
Actual Enrollment
 (submitted: February 19, 2008)
54
Original Actual Enrollment Same as current
Estimated Study Completion Date June 2010
Actual Primary Completion Date October 1996   (Final data collection date for primary outcome measure)
Eligibility Criteria

Inclusion Criteria:

  • Turner syndrome verified by karyotyping

Exclusion Criteria:

  • untreated hypothyroidism or hyperthyroidism
  • present or past malignant diseases
  • clinical liver disease
  • treatment with drugs known to interfere with bone metabolism (e.g. glucocorticoids)
Sex/Gender
Sexes Eligible for Study: Female
Ages 18 Years and older   (Adult, Older Adult)
Accepts Healthy Volunteers Yes
Contacts Contact information is only displayed when the study is recruiting subjects
Listed Location Countries Not Provided
Removed Location Countries  
 
Administrative Information
NCT Number NCT00625001
Other Study ID Numbers 1994/2424
Has Data Monitoring Committee No
U.S. FDA-regulated Product Not Provided
IPD Sharing Statement Not Provided
Responsible Party MD, Dr. Med. Sci Claus Gravholt, University of Aarhus
Study Sponsor University of Aarhus
Collaborators Not Provided
Investigators Not Provided
PRS Account University of Aarhus
Verification Date February 2008