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Prevalence of Pulmonary Hypertension in COPD Patients

This study has been completed.
Sponsor:
Collaborator:
Aarhus University Hospital
Information provided by (Responsible Party):
Charlotte Andersen, University of Aarhus
ClinicalTrials.gov Identifier:
NCT00614900
First received: January 31, 2008
Last updated: September 17, 2012
Last verified: September 2012
January 31, 2008
September 17, 2012
March 2008
March 2011   (Final data collection date for primary outcome measure)
Not Provided
Not Provided
Complete list of historical versions of study NCT00614900 on ClinicalTrials.gov Archive Site
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Prevalence of Pulmonary Hypertension in COPD Patients
Prevalence and Influence of Pulmonary Hypertension in COPD Patients
The prevalence of an increased pulmonary blood pressure amongst patients with chronic obstructive pulmonary disease (COPD)is unclear. So is the impact of abnormal pulmonary blood pressure on symptoms. The aim of this study is to determine the prevalence of an increased pulmonary blood pressure in 200 patients with COPD. Furthermore we will investigate if lung function test results and blood tests can predict an increased pulmonary blood pressure, and explore whether COPD patients with a high pulmonary blood pressure have more symptoms that their co-patients.

The prevalence of pulmonary hypertension in patients with chronic obstructive pulmonary disease (COPD) is unclear. The presence of an abnormally increased pulmonary blood pressure worsens the prognosis of COPD, but the patients are not currently diagnosed or treated for pulmonary hypertension. The aim of this study is to determine the prevalence of pulmonary hypertension in 200 patients with COPD and explore whether it worsens functional capacity and symptoms. Furthermore we will look into whether blood gas values, NT-proBNP, CRP and lung function test result can predict which patients are at risk of having pulmonary hypertension.

Methods: All patients will be screened by echocardiography. Those with signs of pulmonary hypertension will be admitted to right heart catheterization for direct measurements of pulmonary haemodynamics.

All patients will perform a 6 minutes walk test and spirometry. Blood levels of NT-proBNP and CRP will be measured. Life quality by the St. George Questionnaire and contacts to the health care system is also assessed. Differences in these parameters are analyzed among patients with no, moderate or severe pulmonary hypertension.

Observational
Time Perspective: Cross-Sectional
Not Provided
Retention:   Samples With DNA
Description:
Blood samples
Non-Probability Sample
All patients have been admitted to hospital with an exacerbation in COPD in 2006.
  • COPD
  • Pulmonary Hypertension
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
117
March 2011
March 2011   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • Diagnosis of COPD
  • Prior admittance to hospital with exacerbation in COPD
  • Informed consent

Exclusion Criteria:

  • Exacerbation in COPD less than 6 weeks before examination
Sexes Eligible for Study: All
Child, Adult, Senior
No
Contact information is only displayed when the study is recruiting subjects
Denmark
 
 
NCT00614900
PreKPH-08
jnr 2007-0206
No
Not Provided
Not Provided
Charlotte Andersen, University of Aarhus
University of Aarhus
Aarhus University Hospital
Study Director: Ole Hilberg, Md, Dr.med. Aarhus Universitetshospital, Aarhus Sygehus
University of Aarhus
September 2012

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP