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Near Normalisation of BG Improves the Potentiating Effect of GLP-1

This study has been completed.
Sponsor:
Information provided by:
Hvidovre University Hospital
ClinicalTrials.gov Identifier:
NCT00612625
First received: January 16, 2008
Last updated: February 11, 2008
Last verified: January 2008

January 16, 2008
February 11, 2008
February 2004
July 2004   (final data collection date for primary outcome measure)
insulin secretion rate (ISR) were derived by deconvolution of c-peptide. ISR is expressed as pmol/kg/min [ Time Frame: 180 minutes ] [ Designated as safety issue: No ]
Same as current
No Changes Posted
The calculated ISR values was plotted against the ambient plasma glucose. The slopes of this linear relationships were calculated by cross-correlation analysis and is and estimation of beta-cell responsiveness (pmol/kg/min)/mmol/l [ Time Frame: 180 minutes ] [ Designated as safety issue: No ]
Same as current
Not Provided
Not Provided
 
Near Normalisation of BG Improves the Potentiating Effect of GLP-1
Near Normalisation of Blood Glucose Improves the Potentiating Effect of GLP-1 on Glucose Induced Insulin Secretion in Patients With Type 2 Diabetes
The ability of glucagon-like peptide 1 to enhance beta-cell responsiveness to I.v. glucose is impaired in patients with type 2 diabetes mellitus compared with healthy individuals. We investigated whether 4 weeks of near-normalisation og blood glucose improves the potentiation of glucose-stimulated insulin secretion by GLP-1
Not Provided
Interventional
Not Provided
Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Single Group Assignment
Masking: Single Blind (Subject)
Primary Purpose: Basic Science
Diabetes Mellitus Type 2
  • Drug: glucagon-like peptide-1
    continuous infusion of GLP-1 (1½ pmol/kg/min)
  • Drug: Saline
    continuous infusion of saline
  • Experimental: GLP-1
    A graded glucose infusion with an infusion of GLP-1 (1½ pmol/kg/min)
    Intervention: Drug: glucagon-like peptide-1
  • Experimental: Saline
    A graded glucose infusion together with a continuous infusion of saline
    Intervention: Drug: Saline
Højberg PV, Zander M, Vilsbøll T, Knop FK, Krarup T, Vølund A, Holst JJ, Madsbad S. Near normalisation of blood glucose improves the potentiating effect of GLP-1 on glucose-induced insulin secretion in patients with type 2 diabetes. Diabetologia. 2008 Apr;51(4):632-40. doi: 10.1007/s00125-008-0943-x.

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
9
December 2004
July 2004   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Age 18-70 years
  • Type 2 diabetes diagnosed after 30 years of age
  • BMI > 25

Exclusion Criteria:

  • Severe complications to diabetes
  • Abnormal liver og kidney function
  • Haemoglobin below the lower limit
  • Macroalbuminuria
  • Systemic disease
  • Pregnancy
Both
18 Years to 70 Years   (Adult, Senior)
Yes
Contact information is only displayed when the study is recruiting subjects
Denmark
 
NCT00612625
KF 01 - 198/03, KA 01 - 198/03
No
Not Provided
Not Provided
Patricia Verdugo Højberg, MD, PHD, Patricia Verdugo Højberg
Hvidovre University Hospital
Not Provided
Principal Investigator: Patricia V Højberg, MD, PHD University Hospital Hvidovre
Hvidovre University Hospital
January 2008

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP