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Incidence of Ocular Antibodies in Patients With Sturge - Weber Syndrome (SWS)

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00610402
First Posted: February 8, 2008
Last Update Posted: February 10, 2017
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborator:
Mainz University
Information provided by (Responsible Party):
Beckman Laser Institute and Medical Center, University of California, Irvine
January 25, 2008
February 8, 2008
February 10, 2017
July 2007
July 2007   (Final data collection date for primary outcome measure)
Not Provided
Not Provided
Complete list of historical versions of study NCT00610402 on ClinicalTrials.gov Archive Site
Not Provided
Not Provided
Not Provided
Not Provided
 
Incidence of Ocular Antibodies in Patients With Sturge - Weber Syndrome (SWS)
Incidence of Ocular Antibodies in Patients With Sturge - Weber Syndrome (SWS)

Sturge-Weber Syndrome (SWS) is a neurological disorder characterized at birth by seizures and a large port-wine stain birthmark on the forehead and upper eyelid of one side of the face. SWS is also accompanied by an increased pressure within the eye (glaucoma) which can develop very early in life.

Glaucoma represents a group of ocular disorders that are characterized by the loss of retinal ganglion cells and their axons, damage to the optic nerve, and gradual loss of visual field. Recently, several studies provided evidence that there is a potential role of the immune system in the pathogenesis of glaucoma.

These findings suggest that there might be changes in systemic humoral immunity possibly underlying the optic neuropathy in at least some glaucoma patients.

The ocular antibody profile in patients with SWS is unknown.The researchers want to study on blood and tear drop samples from patients with SWS to determine the incidence of ocular antibodies in patients with this syndrome.
Observational
Observational Model: Case-Only
Time Perspective: Prospective
Not Provided
Retention:   Samples Without DNA
Description:
blood sample tear drop sample
Non-Probability Sample
community sample
Sturge - Weber Syndrome (SWS)
Other: blood sample tear drop sample
blood sample tear drop sample
blood sample tear drop sample
blood sample tear drop sample
Intervention: Other: blood sample tear drop sample
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
57
June 2008
July 2007   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • Male and female volunteers with SWS of all ages

Exclusion Criteria:

  • Volunteers without SWS
Sexes Eligible for Study: All
Child, Adult, Senior
No
Contact information is only displayed when the study is recruiting subjects
United States
 
 
NCT00610402
NIH-LAMMP-2006-5691
No
Not Provided
Not Provided
Beckman Laser Institute and Medical Center, University of California, Irvine
University of California, Irvine
Mainz University
Principal Investigator: John S Nelson, M.D,PhD Beckman Laser Institute University of California Irvine
University of California, Irvine
February 2017