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Circulation Improving Resuscitation Care (CIRC) (CIRC)

This study has been completed.
ClinicalTrials.gov Identifier:
First Posted: January 17, 2008
Last Update Posted: September 26, 2017
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Ullevaal University Hospital
Information provided by (Responsible Party):
Zoll Medical Corporation
January 8, 2008
January 17, 2008
March 8, 2014
April 14, 2014
September 26, 2017
January 2008
February 2011   (Final data collection date for primary outcome measure)
Hospital Discharge [ Time Frame: From time of first contact until hospital discharge, up to 90 days. ]
Whether a subject was discharged alive from the hospital or alternatively died prior to discharge.
Hospital Discharge [ Time Frame: Dispatched from hospital ]
Complete list of historical versions of study NCT00597207 on ClinicalTrials.gov Archive Site
  • Neurology [ Time Frame: 30 days ]
  • Sustained ROSC, Survival to 24 Hours, Hospital Discharge With a MRS ≤ 3, Process Outcomes: Number of Shocks, Duration of Pulselessness From 911 Call to ROSC, Hands-on Interval or Other Measures of CPR Quality [ Time Frame: during the case ]
Same as current
Not Provided
Not Provided
Circulation Improving Resuscitation Care (CIRC)
A Randomized Controlled Study Comparing Autopulse To Manual CPR In A CPR-First Protocol For Out-Of-Hospital Cardiac Arrest
During resuscitation of out of hospital cardiac arrest patients the use of a mechanical chest compression device Autopulse will improve survival compared to manual compressions.
Sudden out-of-hospital cardiac arrest (OOH-CA) remains a significant cause of death, in spite of recent declines in overall mortality from cardiovascular disease. Several studies document sub optimal quality of manual chest compressions and this may influence outcome. However, studies comparing manual and mechanical chest compressions have resulted in conflicted results. The investigators think this may be based on methodology and design issues of the trials as much as not focusing on training and experience in operating a mechanical device clinically. Therefore the investigators will focus on these issues and implement three phases in the study (In field training, Run In phase, and Study phase). The investigators will also focus on early use of mechanical CPR after arrival at patient side and randomization at arrival. In order to achieve this the investigators will follow the Norwegian CPR Guidelines with 3 min CPR before defibrillation and the 3 min algorithm. Quality of CPR will be monitored.
Not Provided
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary Purpose: Treatment
  • Cardiac Arrest
  • Cardiopulmonary Resuscitation
  • Device: AutoPulse
    Mechanical device that provides chest compression
  • Other: Manual
    Manual chest compression
  • Experimental: 1
    Mechanical CPR with AutoPulse
    Intervention: Device: AutoPulse
  • 2
    Manual CPR
    Intervention: Other: Manual

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
December 2013
February 2011   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • Patents aged 18 years (or local age of consent) or more who suffer non-traumatic arrest of presumed cardiac etiology in an out-of-hospital setting and who do not meet any of the exclusion criteria below.

Exclusion Criteria:

  • Traumatic arrest (blunt, penetrating, burns)
  • Arrest due to exsanguinations, strangulation, smoke inhalation, drug overdose, electrocution, hanging, drowning.
  • Known or clinically apparent pregnancy
  • Do Not Attempt to Resuscitate (DNAR) orders
  • Apparent patient weight more than 225 kg (500 lbs)
  • Wards of the state
  • Prisoner
  • CPR device other than AutoPulse
  • Patients who are reached after 16 minutes after the time of emergency call (911). This exclusion is determined at the time of CRF abstraction, not during treatment of the patient.

    • If patient is unaccompanied, or accompanied by a person or persons unfamiliar with their his-tory, determination of these exclusion criteria will, perforce, be left to the best estimation of the rescue personnel. At no time, should an attempt to determine these criteria be allowed to delay the administration of life-saving treatment.

      • These criteria will be determined in the best estimation of the rescue personnel, or if the AutoPulse signals that the patient is outside the parameters for AutoPulse deployment.
Sexes Eligible for Study: All
18 Years and older   (Adult, Senior)
Contact information is only displayed when the study is recruiting subjects
Austria,   Netherlands,   United States
Not Provided
Not Provided
Zoll Medical Corporation
Zoll Medical Corporation
Ullevaal University Hospital
Principal Investigator: Lars Wik, MD Ullevaal University Hospital
Principal Investigator: David Persse, MD Houston Fire
Zoll Medical Corporation
April 2014

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP