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Assessment of Left Ventricular Torsion by Echocardiography Study (LVTorsion)

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified June 2008 by The Cleveland Clinic.
Recruitment status was:  Active, not recruiting
ClinicalTrials.gov Identifier:
First Posted: January 10, 2008
Last Update Posted: October 12, 2017
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
The Cleveland Clinic
December 26, 2007
January 10, 2008
October 12, 2017
June 2005
December 2008   (Final data collection date for primary outcome measure)
Myocardial torsion as measured by tissue Doppler echocardiography [ Time Frame: 1 1/2 hours ]
Same as current
Complete list of historical versions of study NCT00589836 on ClinicalTrials.gov Archive Site
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Assessment of Left Ventricular Torsion by Echocardiography Study
Assessment of LV Torsion by Tissue Doppler Echocardiography
The purpose of this study is to learn about the twisting or wringing motion of the heartbeat called torsion which can be seen on ultrasound. This study will help figure out if there is a difference in the how a heart twists at rest and with exercise in people with normal hearts compared to people with HCM (abnormally thickened heart muscle). Volunteers will have an echocardiogram (ultrasound of the heart) while lying on a bed both at rest and while peddling a wheel located at at the foot of the bed. The patients will take about 1 to 1 1/2 hours total and the study will be complete after this procedure.

Left ventricular myocardial torsion (myocardial wringing motion) will be investigated by the use of tissue Doppler echocardiography in both normal and HCM (hypertrophic cardiomyopathy) patients. The objective of this study is to characterize the myocardial torsional behavior in normal and in HCM patients both at rest and while undergoing moderate physiological exercise.

After a routine echocardiographic study, tissue Doppler echocardiogram will be performed before and during supine bicycle exercise. Stress EchoTM Bed with ergometer (supine bicycle) is used during exercise testing. Standard electrocardiogram and blood pressure will be monitored throughout the exercise testing. This procedure will take about 1 to 1 1/2 hours and will not involve any follow-up.

Observational Model: Case Control
Time Perspective: Cross-Sectional
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Non-Probability Sample
Patients undergoing cardiac echocardiography testing in the outpatient department
Hypertrophic Cardiomyopathy
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  • Normal
    Patients with structurally normal hearts
  • HCM
    Patients with hypertrophic cardiomyopathy
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
Unknown status
December 2008
December 2008   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • Male and female patients age 18 to 70 years
  • Patients with hypertrophic cardiomyopathy
  • Patients with the ability to exercise using a supine bicycle
  • Ability to provide informed consent

Exclusion Criteria:

  • Aortic valve stenosis classified as moderate to severe
  • Severe left ventricular obstruction at rest (high gradients > 4m/second)
  • Uncontrolled arrhythmias including atrial fibrillation, atrial flutter, frequent premature ventricular ectopic beats
  • History of sustained ventricular tachyarrhythmia at any time
Sexes Eligible for Study: All
18 Years to 70 Years   (Adult, Senior)
Contact information is only displayed when the study is recruiting subjects
United States
IRB 05-023
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Zoran Popovic, PhD, Cleveland Clinic
The Cleveland Clinic
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Principal Investigator: Zoran Popovic, M.D. The Cleveland Clinic
The Cleveland Clinic
June 2008