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High-resolution Computed Tomography (HRCT) Evaluation of Airway Distensibility in Lung Transplant Recipients

This study is ongoing, but not recruiting participants.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00584181
First Posted: January 2, 2008
Last Update Posted: May 12, 2016
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
The University of Texas Medical Branch, Galveston
December 20, 2007
January 2, 2008
May 12, 2016
August 2007
December 2016   (Final data collection date for primary outcome measure)
Spirometry changes [ Time Frame: Two hours (before and after inhalation of ipratropium) ]
Assessment of changes in spirometry following inhalation of nebulized ipratropium
Not Provided
Complete list of historical versions of study NCT00584181 on ClinicalTrials.gov Archive Site
Lung volumes [ Time Frame: Two hours (before and after inhalation of ipratropium) ]
Assessment of changes in total lung capacity, functional reserve capacity and inspiratory capacity following inhalation of nebulized ipratropium
Not Provided
Radiographic changes in airway caliber [ Time Frame: Two hours (before and after inhalation of ipratropium) ]
Assessment of changes in airway caliber as determined by high resolution chest CT images following inhalation of nebulized ipratropium
Not Provided
 
High-resolution Computed Tomography (HRCT) Evaluation of Airway Distensibility in Lung Transplant Recipients
High Resolution Computed Tomographic Evaluation of Airway Distensibility in Lung Transplant Recipients: A Pilot Study
Lung and heart-lung recipients at the University of Texas Medical Branch who have participated in the "Assessment of Cough Reflex in Lung Transplant Recipients" study who meet the specific study inclusion/exclusion criteria will have one study visit where they will undergo lung volume measurements, followed by high resolution CT scan of the lungs within 2 hours. After the initial CT scan, patients will be given a standard dose of Atrovent, followed thirty minutes later by repeat lung volume measurements and CT scan.
Not Provided
Observational
Observational Model: Cohort
Time Perspective: Prospective
Not Provided
Not Provided
Non-Probability Sample
All patients who participated in the "Assessment of Cough Reflex in Lung Transplant Recipients" study who meet the specific inclusion/exclusion criteria for this study
Unspecified Complication of Lung Transplant
Not Provided
A
All eligible patients will undergo the same procedures
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Active, not recruiting
10
Not Provided
December 2016   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • lung transplant recipients >18 years of age
  • at least 12 months or greater from time of transplantation

Exclusion Criteria:

  • hemodynamic instability
  • hypoxemia
  • pneumonia
  • moderate or large pleural effusion
  • clinical evidence of acute rejection
Sexes Eligible for Study: All
18 Years and older   (Adult, Senior)
No
Contact information is only displayed when the study is recruiting subjects
United States
 
 
NCT00584181
07-247
No
Not Provided
Not Provided
The University of Texas Medical Branch, Galveston
The University of Texas Medical Branch, Galveston
Not Provided
Principal Investigator: Alexander G Duarte, MD University of Texas
The University of Texas Medical Branch, Galveston
May 2016
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