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Ascertainment of Families for Genetic Studies of Familial Lymphoproliferative Disorders

This study is currently recruiting participants.
Verified November 2017 by Memorial Sloan Kettering Cancer Center
Sponsor:
ClinicalTrials.gov Identifier:
NCT00582621
First Posted: December 28, 2007
Last Update Posted: November 8, 2017
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.
Collaborators:
Montefiore Medical Center
St. Jude Children's Research Hospital
Information provided by (Responsible Party):
Memorial Sloan Kettering Cancer Center
December 21, 2007
December 28, 2007
November 8, 2017
July 2000
December 2018   (Final data collection date for primary outcome measure)
To establish a collection of DNA and frozen lymphocytes for the purpose of facilitating genetic laboratory investigations of familial lymphoid neoplasms. [ Time Frame: 2 years ]
Same as current
Complete list of historical versions of study NCT00582621 on ClinicalTrials.gov Archive Site
To perform linkage and candidate gene studies on informative families for the purpose of identifying novel lymphoproliferative syndrome (LPS) predisposition genes. [ Time Frame: 2 years ]
Same as current
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Ascertainment of Families for Genetic Studies of Familial Lymphoproliferative Disorders
Ascertainment of Families for Genetic Studies of Familial Lymphoproliferative Disorders
The purpose of this study is to better understand the genetic causes of Hodgkin's disease (a kind of lymphoma) and non-Hodgkin's lymphoma, as well as multiple myeloma, leukemia, and related diseases. The doctors have identified the patient because 1) they have had a lymphoproliferative disorder such as lymphoma, leukemia, or multiple myeloma, and have a family member with one of these disorders or 2) they are a member of a family with a lymphoproliferative disorder, including Hodgkin's disease and/or, non-Hodgkin's lymphoma or a second cancer after Hodgkin's disease.
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Observational
Observational Model: Family-Based
Time Perspective: Prospective
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Retention:   Samples With DNA
Description:
Blood or alternatively, subjects may provide a saliva or buccal cell sample
Non-Probability Sample
Clinical Genetics Service at MSKCC or to the MSKCC outpatient clinics of the Lymphoma, Multiple Myeloma or Leukemia Services in the Department of Medicine.
  • Lymphoma
  • Leukemia
  • Multiple Myeloma
  • Colon Cancer
  • Renal Cancer
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
500
December 2018
December 2018   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • Patients with lymphoma or lymphoproliferative disease B-cell malignancies, or multiple myeloma accepted for referral to the Cancer Family Clinic of the Department of Human Genetics for genetic counseling, or to the MSKCC outpatient clinics of the Lymphoma, Multiple Myeloma, or Leukemia Services in the Department of Medicine in consultation for treatment who are found on routine history or through a Family History Questionnaire (FHQ) (Appendix A) to have relatives or members of successive generations of the family affected with Hodgkin's disease, non-Hodgkin's lymphoma, lymphoid leukemia, multiple myeloma other lymphoproliferative disease prostate or pancreatic cancers. Patients with lymphoma, associated with colon and renal cancer will be eligible for DNA storage through this protocol. Family members or probands with Hodgkin's disease who are women who received therapeutic irradiation for Hodgkin's disease" or who developed secondary cancers after Hodgkin's disease are also eligible for participation.
  • The criteria for eligibility are broad because the ascertainment by the computerized FHQ does not allow for resolution of different types of lymphoma or different types of leukemia. Patient recall of this information is also imprecise. More accurate family history information will be obtained upon contact of family members and diagnoses will be verified by obtaining pathologic documentation. The spectrum of familial lymphoproliferative syndromes (LPS) may include all types of lymphoma as well as chronic lymphocytic leukemia. This is an additional reason to have a broad eligibility. Subset analysis will be performed on specific types of lymphoid neoplasms. DNA of patients with a family history of lymphoma who have consented to protocol 93-102 ("Ascertainment of Peripheral Blood or Saliva Samples for Genetic Epidemiology Studies of Familial Cancers") will also be eligible for inclusion in this study.
  • Family members of probands including patients, sisters, brothers, halfbrothers and sisters, sons, daughters, grandparents, as well as aunts and uncles are also eligible. An effort will be made to ascertain all living affected and unaffected living relatives in the affected lineage. An emphasis will be on affected sibling pairs and both parents, if alive.
  • Also eligible for inclusion are up to 2000 anonymized familial lymphoma/leukemia samples from Montefiore Medical Center, with information on age of onset, gender, lymphoma or leukemia type, familial relationship, and year of sample collection. No PHI will be used and therefore these samples will be fully and permanently anonymized to MSKCC.
  • As this study involves research that presents no greater than minimal risk to children (see Sec. 46.404 of Federal Regulations part 46), minors are also eligible for participation. The assent of any minor should be obtained before the patient is enrolled into this study, as well as the consent of the legal guardian.

Exclusion Criteria:

Sexes Eligible for Study: All
Child, Adult, Senior
Yes
Contact: Kenneth Offit, MD 646-888-4050
United States
 
 
NCT00582621
00-069
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Memorial Sloan Kettering Cancer Center
Memorial Sloan Kettering Cancer Center
  • Montefiore Medical Center
  • St. Jude Children's Research Hospital
Principal Investigator: Kenneth Offit, MD Memorial Sloan Kettering Cancer Center
Memorial Sloan Kettering Cancer Center
November 2017