Mechanism and Efficacy of Rehabilitation Approaches

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00564005
Recruitment Status : Completed
First Posted : November 27, 2007
Last Update Posted : February 11, 2015
National Science Council, Taiwan
National Health Research Institutes, Taiwan
Information provided by (Responsible Party):
Chang Gung Memorial Hospital

November 25, 2007
November 27, 2007
February 11, 2015
January 2008
December 2010   (Final data collection date for primary outcome measure)
Cortical reorganization and kinematic analysis [ Time Frame: 2008-2010 ]
Same as current
Complete list of historical versions of study NCT00564005 on Archive Site
clinical measures at the impairment, activity, participation levels [ Time Frame: 2008-2010 ]
Same as current
Not Provided
Not Provided
Mechanism and Efficacy of Rehabilitation Approaches
Mechanisms and Long-term Effects of Separate vs. Coupled Rehabilitation Approaches After Stroke
Identify the possible mechanisms and the relative effectiveness of existing rehabilitation approaches that target upper extremity deficits of stroke patients on the ground that these approaches are based on neuroplasticity principles and sound motor control theories.
Comparisons of constraint-induced therapy (CIT) vs. bilateral arm training (BIT)vs. combined therapy were made. Stroke patients will receive one of these three approaches and be evaluated pre- and post-treatment. the treatment will last 3 weeks and 5 days per week. The evaluation will include clinical measures of motor function, ADL, and quality of life, kinematic performance, and activation patterns of cortex.
Not Applicable
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary Purpose: Treatment
Cerebrovascular Accidents
  • Other: Constraint-induced therapy (CIT)
    restraint of the unaffected arm and practice of the affected arm
  • Other: Bilateral arm training (BAT)
    bilateral symmetric, repetitive arm training
  • Other: Combined therapy (CT)
    combined different treatment approaches
  • Behavioral: Control intervention
    Conventional treatment program
  • Experimental: 1
    constraint-induced therapy
    Intervention: Other: Constraint-induced therapy (CIT)
  • Experimental: 2
    bilateral arm training
    Intervention: Other: Bilateral arm training (BAT)
  • Experimental: 3
    combined therapy
    Intervention: Other: Combined therapy (CT)
  • Active Comparator: Control intervention
    Intervention: Behavioral: Control intervention
Wu CY, Chen YA, Lin KC, Chao CP, Chen YT. Constraint-induced therapy with trunk restraint for improving functional outcomes and trunk-arm control after stroke: a randomized controlled trial. Phys Ther. 2012 Apr;92(4):483-92. doi: 10.2522/ptj.20110213. Epub 2012 Jan 6.

*   Includes publications given by the data provider as well as publications identified by Identifier (NCT Number) in Medline.
Same as current
December 2010
December 2010   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • a first-ever clinical cerebrovascular accident patients
  • at least 6 months post-stroke onset
  • premorbid right-hand dominance
  • demonstration of Brunnstrom stage III of the affected upper extremity
  • no excessive spasticity in the joints of the affected upper extremity

Exclusion Criteria:

  • a score of less than 24 on the Mini Mental State Exam
  • poor physical conditions that would interfere with participation
  • excessive pain in any joint that might limit participation
Sexes Eligible for Study: All
40 Years to 75 Years   (Adult, Senior)
Contact information is only displayed when the study is recruiting subjects
Not Provided
Not Provided
Chang Gung Memorial Hospital
Chang Gung Memorial Hospital
  • National Science Council, Taiwan
  • National Health Research Institutes, Taiwan
Principal Investigator: Ching-yi Wu, ScD Department of Occupational Therapy, Chang Gung Univ.
Chang Gung Memorial Hospital
September 2014

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP